Results 41 to 50 of about 178,510 (288)
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Sillages CritiquesThe sleeping beauty is a typical motif in painting and literature, especially fairy-tales: held captive by a century-long slumber or doomed by a poisoned apple, the fairy-tale princess is often brought back from the dead by the kiss of a charming prince.
Adèle Hoareau
doaj +1 more source
Effective gene trapping mediated by Sleeping Beauty transposon.
PLoS ONE, 2012 Gene trapping is a high-throughput approach to elucidate gene functions by disrupting and recapitulating expression of genes in a target genome. A number of transposon-based gene-trapping systems are developed for mutagenesis in cells and model organisms,
Guili Song +5 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Diversity, 2022 Anhydrobiosis is induced by loss of water and indicates dehydration tolerance. Survival of dehydration is possible through changes at different levels of organism organization, including a remarkable reduction in metabolic activity at the cellular level.
Amit Kumar Nagwani +2 more
doaj +1 more source
Perspective Reasoning and the Solution to the Sleeping Beauty Problem [PDF]
, 2018 This paper proposes a new explanation for the paradoxes related to anthropic reasoning. Solutions to the Sleeping Beauty Problem and the Doomsday argument are discussed in detail.
Gao, Xianda
core +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
"Endymion": An assessment "Endymion": An assessment
Ilha do Desterro, 2008 The Greek myth of Endymion tells the story of a beautiful shepherd with whom Cynthia (or Diana, Phoebe) fell in love "when she saw him sleeping on Mt. Latmos. She caused him to sleep for ever that she might enjoy his beauty...
Futin Buffara Antunes
doaj +2 more sources
Molecular Therapy: Nucleic Acids, 2016 The Sleeping Beauty (SB) transposon system has been shown to enable long-term gene expression by integrating new sequences into host cell chromosomes. We found that the recently reported SB100x hyperactive transposase conferred a surprisingly high level ...
Kelly M Podetz-Pedersen +4 more
doaj +1 more source
When Beauty Goes to Sleep: an analysis of the symbolism behind the sleeping beauty tale [PDF]
, 2015 Approaching the world of the fairy tale as an adult, one soon realizes that things are not what they once seemed during story time in bed. Something that once appeared so innocent and simple can become rather complex when digging into its origin. A kiss,
Padovani, Francesca
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