Results 71 to 80 of about 223,441 (320)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

Network Slicing in 6G: A Strategic Framework for IoT in Smart Cities

open access: yesSensors
The emergence of 6G communication technologies brings both opportunities and challenges for the Internet of Things (IoT) in smart cities. In this paper, we introduce an advanced network slicing framework designed to meet the complex demands of 6G smart ...
Ahmed M. Alwakeel, Abdulrahman K. Alnaim
doaj   +1 more source

Current economic and sensitivity analysis for ID slicing of 4 inch and 6 inch diameter silicon ingots for photovoltaic applications [PDF]

open access: yes, 1982
The economics and sensitivities of slicing large diameter silicon ingots for photovoltaic applications were examined. Current economics and slicing add on cost sensitivities are calculated using variable parameters for blade life, slicing yield, and ...
Johnson, C. M., Roberts, E. G.
core   +1 more source

New Formalism for Numerical Relativity

open access: yes, 1995
We present a new formulation of the Einstein equations that casts them in an explicitly first order, flux-conservative, hyperbolic form. We show that this now can be done for a wide class of time slicing conditions, including maximal slicing, making it ...
A. E. Fischer   +18 more
core   +1 more source

Towards Log Slicing

open access: yes, 2023
AbstractThis short paper takes initial steps towards developing a novel approach, called log slicing, that aims to answer a practical question in the field of log analysis: Can we automatically identify log messages related to a specific message (e.g., an error message)?
Dawes, J.H., Shin, D., Bianculli, D.
openaire   +3 more sources

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

open access: yesMolecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon   +4 more
wiley   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

open access: yesFEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani   +7 more
wiley   +1 more source

Slicing Bing doubles

open access: yes, 2006
Bing doubling is an operation which produces a 2-component boundary link B(K) from a knot K. If K is slice, then B(K) is easily seen to be boundary slice. In this paper, we investigate whether the converse holds.
Bing   +8 more
core   +2 more sources

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

open access: yesFEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp   +13 more
wiley   +1 more source

Home - About - Disclaimer - Privacy