Results 41 to 50 of about 1,084,124 (289)
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis
FEBS Letters, EarlyView.This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng +8 more
wiley +1 more source
A Concept of the Effective Surface Profile to Predict the Roughness Parameters of Worn Surface
Frontiers in Mechanical Engineering, 2019 A new concept of the effective surface profile is proposed to facilitate the prediction of the worn surface texture at sliding friction. The effective surface profile is a 2D height characteristic that consists of the asperities of surface superimposed ...
Alexander Kovalev +3 more
doaj +1 more source
Sliding invariants and classification of singular holomorphic foliations in the plane [PDF]
Annales de l'Institut Fourier, 2015 By introducing a new invariant called the set of slidings, we give a complete strict classification of the class of germs of non-dicritical holomorphic foliations in the plan whose Camacho-Sad indices are not rational. Moreover, we will show that, in this class, the new invariant is finitely determined.
openaire +5 more sources
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
, 2015 Contact behavior of a rigid cylindrical punch sliding on an elastically graded half-plane with shear modulus gradient variation in an arbitrary direction is investigated.
Chen PJ +3 more
core +1 more source
Mechanics of sliding frictional contact for a graded orthotropic half-plane
Acta Mechanica, 2015 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Aysegul Kucuksucu +2 more
openaire +5 more sources
Liquid drops sliding down an inclined plane [PDF]
Transactions of the American Mathematical Society, 2014 33 pages, 2 ...
Kim, Inwon, Mellet, Antoine
openaire +3 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source