Results 61 to 70 of about 1,084,124 (289)

Electrically assisted drop sliding on inclined planes

Applied Physics Letters, 2011
We demonstrate that electrowetting using alternating current (ac) voltage can be used to overcome pinning of small drops due to omnipresent heterogeneities on solid surfaces. By balancing contact angle hysteresis with gravity on inclined planes, we find that the critical electrowetting number for mobilizing drops is consistent with the voltage ...
't Mannetje, D.J.C.M., Murade, C.U., van den Ende, D., Mugele, F.   +3 more
openaire   +2 more sources

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Calculation of passive earth pressure of cohesive soil based on Culmann's method

Water Science and Engineering, 2011
Based on the sliding plane hypothesis of Coulumb earth pressure theory, a new method for calculation of the passive earth pressure of cohesive soil was constructed with Culmann's graphical construction.
Hai-feng Lu, Bao-yuan Yuan
doaj   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Combined static and sliding friction on an inclined plane

European Journal of Physics, 2023
Abstract The friction force on a circular object rolling without sliding down an inclined plane is due to static friction. If the object commences in a sliding mode at the top of the incline, and if the incline angle is small, then a small additional sliding friction force arises to reduce the sliding speed of the contact point to zero ...
openaire   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Effects of Fiber Structure on Boundary Lubrication Properties of Concentrated Cellulose Nanofiber Moldings

Tribology Online
100% cellulose nanofiber (CNF) moldings have attracted attention as next-generation biomass-derived sliding materials. However, the effects of fiber diameter and fiber orientation on their boundary lubrication properties remain poorly understood. In this
Hikaru Okubo, Rizuki Maruo, Ken Nakano, Shinya Sasaki   +3 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Research on response characteristics of loess slope and disaster mechanism caused by structural plane extension under excavation

Scientific Reports
Geological disasters occur frequently in the Loess Plateau due to the joint fissures in the strata and human engineering activities. Against this background, the deformation and failure mode of the loess slope with the structural plane under excavation ...
Ranke Fang, Longsheng Deng, Wen Fan, Gang Yang, Dong Tang, Amini Mohammad   +5 more
doaj   +1 more source