Results 201 to 210 of about 7,938 (247)

Potential field reconstruction-based path planning system for autonomous vehicle with enhancing stability. [PDF]

PLoS One
Fu Z, Liu Z, Tan W, Chen K.
europepmc   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Multiphysics model for designing magnetic bead collection processes on centrifugal microfluidic platforms. [PDF]

RSC Adv
Wimmer J, Planchette C, Holzapfel GA, Rienmüller T.   +3 more
europepmc   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Differential Accumulation Dynamics of Organic Matter in the Central and Eastern Bohai Bay Basin (Eastern China): Implications for Tectonic Activity. [PDF]

ACS Omega
Li Y, Chen Y, Ma Z, Pan K, Xu Y, Wu X, Zhang R, Song L, Ding Q, Qu L, Zhu Q.   +10 more
europepmc   +1 more source

A dual-capability digital portrait framework for identifying community age-friendly service needs. [PDF]

BMC Geriatr
Xue J, Guo W, Wang G.
europepmc   +1 more source

Twinning-Dominated Plasticity and Structural Stability of NiCoCrX_0.1 (X= Mo, Ti) MEA under 52 GPa Pressure. [PDF]

ACS Omega
Ding B, Pu J, Zeng Y, Liang H, Li T, Zhang W.   +5 more
europepmc   +1 more source

An Exploratory Study on Injury Patterns and Clinical Characteristics of Sports-Related Oral and Maxillofacial Trauma: A Single-Center Retrospective Study. [PDF]

Craniomaxillofac Trauma Reconstr
Ayasaka K, Matsuda Y, Tatsumi H, Fujioka-Kobayashi M, Norioka S, Morioka R, Somoto M, Sonoyama-Osako R, Kanno T.   +8 more
europepmc   +1 more source

The breaking point where repeat expansion triggers neuronal collapse in Huntington's disease. [PDF]

Cell Genom
Flower MD, Tabrizi SJ.
europepmc   +1 more source

Integration of Multi-Sensor Fusion and Decision-Making Architecture for Autonomous Vehicles in Multi-Object Traffic Conditions. [PDF]

Sensors (Basel)
Nguyen HN, Luong TN, Minh TP, Hong NMT, Anh KT, Hong QB, Bach NPV.   +6 more
europepmc   +1 more source