Results 41 to 50 of about 2,214 (212)

Simulation Investigation on Application of Powder Metallurgy Damping Effect in Water Hydraulic Pump

MATEC Web of Conferences, 2018
Over the years, the hydrostatic balance slipper is often used to make the hydraulic lubrication film formed between the swash plate and the slipper. In this paper, a slipper containing the powder metallurgy (PM) composite material is proposed. The porous
Shi Weijie, Luo Xiaohui, Zhang Zuti, Wang Huawei, Zhu Yuquan   +4 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Des contes des mille et une nuits à la pantoufle de Marignier (1730)

Fééries, 2007
From the Arabian Nights to Marignier’s Pantoufle (1730): an Example of Oriental Influence on xviith - Century TheaterIn a play written to celebrate actor Gabriel Vincent Thevenard’s wedding, Marignier draws his inspiration from fashionable Oriental tales,
Isabelle Degauque
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Dynamic Prediction Model for Uneven Slipper Wear Under Complex Lubrication Conditions Considering Lubrication–Wear Coupling

Lubricants
It is difficult to experimentally determine the real-time wear coefficient of a slipper pair under complex lubrication conditions. To address this challenge, this study proposes a predictive method for slipper wear, eliminating the need for experimental ...
Hu Mo, Shigang Qin, Wei Zhou, Yunan Yang, Penghui Duan, Fu Peng   +5 more
doaj   +1 more source

Dynamic Analysis of Shearer Traction Unit Considering the Longitudinal Swing

Energies, 2020
Shearer traction failure occurs frequently, which seriously restricts the safe and efficient mining of coal. However, the influence of the shearer’s posture on traction has not been fully considered in the existing research.
Dejian Ma, Xin Zhang, Lirong Wan, Qingliang Zeng, Hongen Ge   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

A novel extraction method for useful component of vibration signal combining variational mode decomposition and relative entropy

AIP Advances, 2021
In condition monitoring and prognostics health management, it is very important to extract the useful components of equipment state signals. In this paper, combining variational mode decomposition (VMD) and relative entropy (RE), a novel approach is ...
Yong Zhu, Quanlin Wang, Yangding Wang, Shouqi Yuan, Shengnan Tang, Zhijian Zheng   +5 more
doaj   +1 more source