Results 41 to 50 of about 2,287 (255)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

CFD Simulation of the slipper dynamics during variable displacement operations in a swash-plate type axial piston pump

International Journal of Thermofluids
This paper investigates the effects of the displacement variation in swash plate type axial piston pumps on the dynamics of a vented grooved slipper.
G. Muzzioli, F. Orlandi, M. Venturelli, M. Milani, L. Montorsi   +4 more
doaj   +1 more source

Simulation Investigation on Application of Powder Metallurgy Damping Effect in Water Hydraulic Pump

MATEC Web of Conferences, 2018
Over the years, the hydrostatic balance slipper is often used to make the hydraulic lubrication film formed between the swash plate and the slipper. In this paper, a slipper containing the powder metallurgy (PM) composite material is proposed. The porous
Shi Weijie, Luo Xiaohui, Zhang Zuti, Wang Huawei, Zhu Yuquan   +4 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Dynamic Prediction Model for Uneven Slipper Wear Under Complex Lubrication Conditions Considering Lubrication–Wear Coupling

Lubricants
It is difficult to experimentally determine the real-time wear coefficient of a slipper pair under complex lubrication conditions. To address this challenge, this study proposes a predictive method for slipper wear, eliminating the need for experimental ...
Hu Mo, Shigang Qin, Wei Zhou, Yunan Yang, Penghui Duan, Fu Peng   +5 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Des contes des mille et une nuits à la pantoufle de Marignier (1730)

Fééries, 2007
From the Arabian Nights to Marignier’s Pantoufle (1730): an Example of Oriental Influence on xviith - Century TheaterIn a play written to celebrate actor Gabriel Vincent Thevenard’s wedding, Marignier draws his inspiration from fashionable Oriental tales,
Isabelle Degauque
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Dynamic Analysis of Shearer Traction Unit Considering the Longitudinal Swing

Energies, 2020
Shearer traction failure occurs frequently, which seriously restricts the safe and efficient mining of coal. However, the influence of the shearer’s posture on traction has not been fully considered in the existing research.
Dejian Ma, Xin Zhang, Lirong Wan, Qingliang Zeng, Hongen Ge   +4 more
doaj   +1 more source