Results 51 to 60 of about 58,137 (298)

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

CFD Simulation of the slipper dynamics during variable displacement operations in a swash-plate type axial piston pump

International Journal of Thermofluids
This paper investigates the effects of the displacement variation in swash plate type axial piston pumps on the dynamics of a vented grooved slipper.
G. Muzzioli, F. Orlandi, M. Venturelli, M. Milani, L. Montorsi   +4 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Eelgrass Habitat Creation in Nantucket Harbor, Massachusetts [PDF]

, 2012
In response to eelgrass habitat losses associated with development and marine activities in and around Nantucket Harbor, a plan to restore a meadow by transplanting eelgrass to previously vegetated areas was developed in conjunction with the Nantucket ...
Burdick, David M, Moore, Gregg, Peter, Chris   +2 more
core   +1 more source

Ethics and exclusion: representations of sovereignty in Australia’s approach to asylum-seekers [PDF]

, 2006
From 2001, the Australian government has justified a hard-line approach to asylum-seekers on the basis of the need to preserve its sovereignty. This article critically evaluates this justification, arguing that the conception of sovereignty as the ‘right
Gelber, Katherine, McDonald, Matt
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Dynamic Prediction Model for Uneven Slipper Wear Under Complex Lubrication Conditions Considering Lubrication–Wear Coupling

Lubricants
It is difficult to experimentally determine the real-time wear coefficient of a slipper pair under complex lubrication conditions. To address this challenge, this study proposes a predictive method for slipper wear, eliminating the need for experimental ...
Hu Mo, Shigang Qin, Wei Zhou, Yunan Yang, Penghui Duan, Fu Peng   +5 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Dynamic Analysis of Shearer Traction Unit Considering the Longitudinal Swing

Energies, 2020
Shearer traction failure occurs frequently, which seriously restricts the safe and efficient mining of coal. However, the influence of the shearer’s posture on traction has not been fully considered in the existing research.
Dejian Ma, Xin Zhang, Lirong Wan, Qingliang Zeng, Hongen Ge   +4 more
doaj   +1 more source

A novel extraction method for useful component of vibration signal combining variational mode decomposition and relative entropy

AIP Advances, 2021
In condition monitoring and prognostics health management, it is very important to extract the useful components of equipment state signals. In this paper, combining variational mode decomposition (VMD) and relative entropy (RE), a novel approach is ...
Yong Zhu, Quanlin Wang, Yangding Wang, Shouqi Yuan, Shengnan Tang, Zhijian Zheng   +5 more
doaj   +1 more source