Results 41 to 50 of about 87,392 (301)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Slips, trips and falls in crowds [PDF]

, 2018
Crowd situations are commonplace and involve circumstances known to lead to slips, trips and falls (STF). Data from focus groups with crowd participants (5 groups, n = 35 individuals); observations of crowd situations (n = 55); and interviews with crowd ...
Haslam, Roger, Roger Haslam, Victoria Filingeri, Filingeri, Victoria, Roger Haslam (1258251), Victoria Filingeri (4434481)   +5 more
core   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Preventing slips and falls through leisure-time physical activity: findings from a study of limited-service restaurants. [PDF]

PLoS ONE, 2014
Physical activity has been shown to be beneficial at improving health in some medical conditions and in preventing injury. Epidemiologic studies suggest that physical activity is one factor associated with a decreased risk for slips and falls in the ...
Alberto J Caban-Martinez, Theodore K Courtney, Wen-Ruey Chang, David A Lombardi, Yueng-Hsiang Huang, Melanye J Brennan, Melissa J Perry, Jeffrey N Katz, Santosh K Verma   +8 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Hoboken - New Ferry Slips at Hoboken Terminal

, 2012
In 1989 ferry service was reintroduced with New York Waterways providing service from and to Hoboken and Manhattan. As a result, Hoboken Terminal currently provides travelers multiple transit options including commuter rail, light rail, bus, PATH and ...
Beards, Daniel E.
core   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

Management of slips and its effect on growth and production of 'Pérola' pineapple plants

Revista Brasileira de Fruticultura, 2003
The lack of good quality planting material has limited the expansion and contributed to yield reduction of the Brazilian pineapple culture. Alternatives of 'Pérola' pineapple slips management were studied aiming at obtaining superior planting material ...
Reinhardt Domingo Haroldo, Souza Ana Patrícia Mascarenhas, Caldas Ranulfo Correa, Alcântara José dos Prazeres, Almeida Alberto Alves de   +4 more
doaj  

The Effects of an Acute Exposure of Virtual vs. Real Slip and Trip Perturbations on Postural Control

Virtual Worlds
Background: Current methods of postural control assessments and interventions to improve postural stability and thereby prevent falls often fail to incorporate the hazardous perturbation situations that frequently accompany falls.
Nathan O. Conner, Harish Chander, Hunter Derby, William C. Pannell, Jacob B. Daniels, Adam C. Knight   +5 more
doaj   +1 more source