Results 51 to 60 of about 152,103 (312)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Heat transfer characteristics in rotating coaxial cylinders with axial slits

Nihon Kikai Gakkai ronbunshu, 2017
Toward the improvement of performance of the electric vehicle (EV), the design of the motor shape appropriate to heat removal is important. A typical EV motor is composed of a pair of coaxial cylinders with a fixed outer cylinder (stator) and a rotating ...
Tomohisa YUASA, Yutaka ABE, Satoru HIRANO   +2 more
doaj   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source

Analysis of Spectral Characteristics of Sound Waves Scattered from a Cracked Cylindrical Elastic Shell Filled with a Viscous Fluid

Archives of Acoustics, 2013
The scattering of plane steady-state sound waves from a viscous fluid-filled thin cylindrical shell weak- ened by a long linear slit and submerged in an ideal fluid is studied. For the description of vibrations of elastic objects the Kirchhoff–Love shell-
Olexa PIDDUBNIAK, Nadia PIDDUBNIAK
doaj  

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Gut microbiota contributes to the maintenance of sublingually induced regulatory T cells and tolerance in mice

Allergology International
Background: Sublingual immunotherapy (SLIT) involves the induction of allergen-specific regulatory T (Treg) cells in the oral mucosa-draining submandibular lymph nodes (LNs).
Saka Winias, Kanan Bando, Boonnapa Temtanapat, Masato Nakano, Masahiro Saito, Shunji Sugawara, Mitsuko Komatsu, Akiyoshi Hirayama, Shinji Fukuda, Takaaki Abe, Kentaro Mizuta, Masahiro Iikubo, Yukinori Tanaka   +12 more
doaj   +1 more source

Adjustable Optical Slit Based on the Phase Type Spatial Light Modulator

IEEE Photonics Journal, 2019
In this paper, we propose an adjustable optical slit based on a phase type spatial light modulator (SLM). The adjustable optical slit consists of two polarized beam splitters and one SLM. The SLM is used to modulate the phase of light.
Di Wang, Chao Liu, Qiong-Hua Wang
doaj   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Slit [PDF]

, 2008
Tamra E. Werbowetski-Ogilvie, Mohamad Seyed Sadr, Rolando F. Del Maestro   +2 more
  +4 more sources