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European Journal of Surgical Oncology (EJSO), 2008 The extent to which the location of micrometastases (MIC) or isolated tumor cells (ITC) in sentinel lymph nodes (SLNs) is correlated with the risk of downstream metastases is still unknown. This study examined this issue and compared the impact of MIC/ITC location with other established risk factors.Paraffin slides of SLNs with MIC/ITC-involvement ...
J, Li +7 more
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Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin
International Journal of Pharmaceutics, 2002 Aim of this study was to evaluate solid lipid nanoparticles (SLN) as carriers for topical ocular delivery of tobramycin (TOB). The SLN were in the colloidal size range (average diameter below 100 nm; polydispersity index below 0.2) and contained 2.5% TOB
Susi Burgalassi +2 more
exaly +2 more sources
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Ophthalmic Applications of SLN and NLC
Current Pharmaceutical Design, 2018The eyes are among the most readily accessible organs in terms of location in the body, yet drug delivery to eye tissues is particularly problematic. The anatomy, physiology and biochemistry of the eye limit the ophthalmic delivery of drugs. Numerous strategies in ophthalmic drug delivery have been made to expand the bioavailability and to prolong the ...
Neslihan Ustundag, Okur +1 more
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SLN mapping in colorectal cancer
The Lancet Oncology, 2011In van der Pas and colleagues’ systematic review and meta-analysis of studies describing sentinel-lymphnode (SLN) mapping in patients with colorectal cancer, the authors report a 0·76 (95% CI 0·72–0·80) mean overall sensitivity of the SLN procedure; however, when restricted to eight studies with a high-quality SLN procedure, the sensitivity rose to 0 ...
Oddmund, Nordgård, Rune, Smaaland
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Integrate Fuzzy Logic into SLN
2011 Seventh International Conference on Semantics, Knowledge and Grids, 2011SLN is a loosely coupled semantic data model assigned for the network resource management. Integrating fuzzy logic into SLN can be used to handle the ambiguity, uncertainty and imprecision. This paper proposes a novel data model of fuzzy semantic link network, and provides membership functions used to define the fuzzy semantic association degree ...
Ke Ren +3 more
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Pharmaceutical Research, 2005
Recently, colloidal dispersions made of mixtures from solid and liquid lipids have been described to overcome the poor drug loading capacity of solid lipid nanoparticles (SLN). It has been proposed that these nanostructured lipid carriers (NLC) are composed of oily droplets, which are embedded in a solid lipid matrix.
Katja, Jores +4 more
openaire +3 more sources
Recently, colloidal dispersions made of mixtures from solid and liquid lipids have been described to overcome the poor drug loading capacity of solid lipid nanoparticles (SLN). It has been proposed that these nanostructured lipid carriers (NLC) are composed of oily droplets, which are embedded in a solid lipid matrix.
Katja, Jores +4 more
openaire +3 more sources
SLN and NLC for topical delivery of ketoconazole
Journal of Microencapsulation, 2005The clinical use of ketoconazole has been related to some adverse effects in healthy adults, specially local reactions, such as severe irritation, pruritus and stinging. The purpose of the present work is the assessment of ketoconazole stability in aqueous SLN and NLC dispersions, as well as the physicochemical stability of these lipid nanoparticles ...
E B, Souto, R H, Müller
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Semantic Cloud Based on SLN and ALN
2009 Fifth International Conference on Semantics, Knowledge and Grid, 2009Clouding computing is considered as one of the most promising computing paradigms. Most already existing systems, which provide cloud computing, only pay attention to aggregating resources with the same computing capability and provide user with local optimized and discontinuous results.
Fangfang Liu 0008 +3 more
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