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Solid Lipid Nanoparticles

Encyclopedia, 2022
Solid lipid nanoparticles (SLNs) are produced from physiologically biocompatible lipids. They have been proven to improve solubility, cellular uptake, and stability, reduce enzyme degradation, and prolong the circulation time of various drugs.
Thi-Thao-Linh Nguyen, Van-An Duong
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Design of Experiments in the Formulation and Characterization of 3D-Printed Vaginal Films Loaded with Curcumin Solid Lipid Nanoparticles for Cervical Dysplasia [PDF]

Pharmaceuticals
Background/Objectives: Cervical dysplasia, a precursor to cervical cancer, represents a significant global health challenge, particularly in regions like Central America, Africa, and Southeast Asia.
Mahek Gulani, Dedeepya Pasupuleti, Yash Harsoda, Snehitha Akkineni, Sarthak Shah, Tanisha Manoj Arte, Emmanuel Adediran, Amarae Ferguson, Nigel D’Souza, Aditi Satoskar, Mohammad Uddin, Lisa Flowers, Martin J. D’Souza   +12 more
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Solid Lipid Nanoparticles (SLN): Formulation and Fabrication

Pharmaceutical Sciences and Research, 2023
Solid lipid nanoparticles (SLN) have emerged as a novel drug delivery system and have been utilized for delivering various kinds of drugs since the 1990s. These particles may consist of multiple solid lipids, including glycerides, waxes, and fatty acids,
Gabriella F. Punu, Yahdiana Harahap, Qonita Kurnia Anjani, Pietradewi Hartrianti, Ryan F. Donnelly, Delly Ramadon   +5 more
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Solid Lipid Nanoparticles vs. Nanostructured Lipid Carriers: A Comparative Review

Pharmaceutics, 2023
Solid–lipid nanoparticles and nanostructured lipid carriers are delivery systems for the delivery of drugs and other bioactives used in diagnosis, therapy, and treatment procedures. These nanocarriers may enhance the solubility and permeability of drugs,
Cláudia Viegas, Ana B. Patrício, João M. Prata, Akhtar Nadhman, Pavan Kumar Chintamaneni, Pedro Fonte   +5 more
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Central Composite Design for Formulation and Optimization of Solid Lipid Nanoparticles to Enhance Oral Bioavailability of Acyclovir

Molecules, 2021
Treatment of herpes simplex infection requires high and frequent doses of oral acyclovir to attain its maximum therapeutic effect. The current therapeutic regimen of acyclovir is known to cause unwarranted dose-related adverse effects, including acute ...
Haniza Hassan, Siti Khadijah Adam, Ekram Alias, Meor Mohd Redzuan Meor Mohd Affandi, Ahmad Fuad Shamsuddin, Rusliza Basir   +5 more
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Ultrasmall Solid-Lipid Nanoparticles via the Polysorbate Sorbitan Phase-Inversion Temperature Technique: A Promising Vehicle for Antioxidant Delivery into the Skin

Pharmaceutics, 2023
Solid lipid nanoparticles promote skin hydration via stratum corneum occlusion, which prevents water loss by evaporation, and via the reinforcement of the skin’s lipid-film barrier, which occurs through the adhesion of the nanoparticles to the stratum ...
Francesca Della Sala, Assunta Borzacchiello, Chiara Dianzani, Elisabetta Muntoni, Monica Argenziano, Maria Teresa Capucchio, Maria Carmen Valsania, Annalisa Bozza, Sara Garelli, Maria Di Muro, Franco Scorziello, Luigi Battaglia   +11 more
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Preclinical Evaluation of Lipid-Based Nanosystems

Pharmaceutics, 2021
The use of lipid-based nanosystems, including lipid nanoparticles (solid lipid nanoparticles—SLN, and nanostructured lipid carriers—NLC), nanoemulsions, and liposomes, among others, is widespread [...]
Ana Catarina Silva, José Manuel Sousa Lobo   +1 more
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Lipid Nanoparticles Functionalized with Antibodies for Anticancer Drug Therapy

Pharmaceutics, 2023
Nanotechnology takes the lead in providing new therapeutic options for cancer patients. In the last decades, lipid-based nanoparticles—solid lipid nanoparticles (SLNs), nanostructured lipid carriers (NLCs), liposomes, and lipid–polymer hybrid ...
Ana Camila Marques, Paulo C. Costa, Sérgia Velho, Maria Helena Amaral   +3 more
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Editorial—Current Insights on Lipid-Based Nanosystems

Pharmaceuticals, 2022
Lipid-based nanosystems, including solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC), cationic lipid nanoparticles, nanoemulsions and liposomes, have been extensively studied to improve drug delivery through different administration
Ana Catarina Silva, João Nuno Moreira, José Manuel Sousa Lobo   +2 more
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The Potential of Caffeic Acid Lipid Nanoparticulate Systems for Skin Application: In Vitro Assays to Assess Delivery and Antioxidant Effect

Nanomaterials, 2021
The object of this study is a comparison between solid lipid nanoparticles and ethosomes for caffeic acid delivery through the skin. Caffeic acid is a potent antioxidant molecule whose cutaneous administration is hampered by its low solubility and scarce
Supandeep Singh Hallan, Maddalena Sguizzato, Markus Drechsler, Paolo Mariani, Leda Montesi, Rita Cortesi, Sebastian Björklund, Tautgirdas Ruzgas, Elisabetta Esposito   +8 more
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