Results 101 to 110 of about 2,508,126 (264)

How One NYC Hospital Handled the Covid-19 Pandemic- The Chief Residents’ Perspective

Marshall Journal of Medicine, 2021
Sunny Arora, Krystyna Bronchard, Michaela Murphy, Stephen J. Peterson   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Comparison of stability analysis methods for safe design of volcanic rock slope

Journal of Degraded and Mining Lands Management
The performance of the stability chart (SC), limit equilibrium (LE), and finite element (FE) methods for stability analysis of weathered volcanic rock slopes under static and earthquake loads is not fully understood.
I Gde Budi Indrawan, Sunardi, Ardian Baroto Murti, Rifki Alfrianto   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Degeneracy slopes, boundary slopes and exceptional surgery slopes

13 pages.
openaire   +2 more sources

The Strong Screening Rule for SLOPE

, 2020
Extracting relevant features from data sets where the number of observations ($n$) is much smaller then the number of predictors ($p$) is a major challenge in modern statistics. Sorted L-One Penalized Estimation (SLOPE), a generalization of the lasso, is
Bogdan, Małgorzata, Larsson, Johan, Wallin, Jonas   +2 more
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Landslide topology uncovers failure movements

Nature Communications
The death toll and monetary damages from landslides continue to rise despite advancements in predictive modeling. These models’ performances are limited as landslide databases used in developing them often miss crucial information, e.g., underlying ...
Kushanav Bhuyan, Kamal Rana, Joaquin V. Ferrer, Fabrice Cotton, Ugur Ozturk, Filippo Catani, Nishant Malik   +6 more
doaj   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Modeling of operational performance parameters applied in mechanized harvest of coffee

Revista Brasileira de Engenharia Agrícola e Ambiental
In super-mechanized coffee harvesting system, all operations are performed mechanically. In order to improve the logistics of mechanized agricultural operations, the knowledge on the variables that affect the operational performance can generate models ...
João P. B. Cunha, Fabio M. da Silva, Ednilton T. de Andrade, Luis C. C. Carvalho   +3 more
doaj   +1 more source