Results 121 to 130 of about 1,049,594 (310)
The extent and an analysis of shallow failures on the slopes of highway earthworks [PDF]
, 1991 The reported incidences of shallow failures on the slopes of highway earthworks have increased in recent years. This Thesis includes a study of the extent of this problem, the likely factors contributing to failure, and presents the results of ...
Perry, John
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Stability analysis of an earth embankment subjected to rainfall infiltration - Analisi di stabilità di un rilevato in terra soggetto ad infiltrazione di acque di pioggia [PDF]
, 2013 In the present thesis, an attempt was made to study, with a numerical software, how the rainfall infiltration influences the stresses and the behavior of a soil embankment according to different hydraulic permeability values and rainfall intensities.
Bertoldo, Daniele
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Run-up tests on a permeable slope
, 1999 This report is the result of the Master of Science thesis of the author, at the Delft University of Technology, sub-Faculty of Civil Engineering. Although a lot is known nowadays about the run-up on smooth and impermeable slopes as well as the run-up on ...
Witteman, E.F.C. (author) +1 more
core +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Slope-stability assessments using finite-element limit-analysis methods
, 2017 This paper utilizes finite-element limit-analysis methods to investigate the stability of slopes of various properties and in nature. Specifically, a slope with a soft (weak material) band, a postquake slope, and rock slopes were investigated.
AJ Li (14531738) +3 more
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Omni-directional Walking of a Quadruped Robot on a Slope
, 2004 In this study, we discuss omni-directional walking of a quadruped robot to walk on a slope. A method for successive gait-transition on a slope with specified body posture is introduced. Using this method, a trade-off between the moving speed and the body
L Zhang +7 more
core +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source