Results 71 to 80 of about 2,523,320 (279)

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Shift from proactive to defensive response in seashore paspalum under escalating light intensity: Modulation by carbon-nitrogen relations

Industrial Crops and Products
As a widely cultivated perennial turfgrass, seashore paspalum (Paspalum vaginatum Sw.) exhibits plasticity in biomass allocation and stress tolerance phenotypes, with growth-resistance trade-offs critically influenced by light intensity.
Xiaowei Ding, Jiabao Chen, Liangying Shen, Xiangyu Han, Yufeng Chen, Huiping Zhou, Liebao Han   +6 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Policing the Arctic: The North Slope of Alaska [PDF]

, 1993
An abbreviated version of this paper, which excluded the NSBDPS employee survey results, was published as: Trostle, Lawrence C.; & Angell, John E. (1994). "Policing the Arctic: The North Slope of Alaska." Journal of Contemporary Criminal Justice 10(2)
Angell, John E., Trostle, Lawrence C.
core  

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Niches, interspecific associations, and community stability of main understory regeneration species after understory removal in temperate forests

Frontiers in Plant Science
IntroductionUnderstory removal is frequently used to relieve the renewal pressure on trees and promote the growth capability of trees for maintaining community stability, while the lack of previous study on temperate forests limits our assessment of the ...
Yanyan Zhang, Yanyan Zhang, Wangming Zhou, Quan Yuan, Quan Yuan, Quan Yuan, Jiaojiao Deng, Jiaojiao Deng, Li Zhou, Li Zhou, Dapao Yu, Dapao Yu   +11 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Restructuring lucerne planting can improve production and environmental co-benefits in Northwest China

Agricultural Water Management
As China's cornerstone lucerne production region, Gansu Province plays a pivotal role in sustaining national forage security and livestock systems, yet the climate resilience of this strategic crop remains critically unassessed.
Huiping Zhou, Xiaowei Ding, Jiabao Chen, David Parsons, Liebao Han   +4 more
doaj   +1 more source

Influência da declividade do solo e da energia cinética de chuvas simuladas no processo de erosão entre sulcos Influence of the soil slope and kinetic energy of simulated precipitation in the channel interrill erosion process

Revista Brasileira de Engenharia Agrícola e Ambiental, 2001
Utilizou-se um simulador de chuvas e um canal de solo para se avaliar o efeito da declividade da superfície do solo e da energia cinética decorrente das chuvas simuladas nas perdas de solo em áreas entre sulcos.
Ricardo S.S. Amorim, Demetrius D. da Silva, Fernando F. Pruski, Antonio T. de Matos   +3 more
doaj   +1 more source