Results 71 to 80 of about 636,370 (268)
Frontiers in Plant ScienceIntroductionThe objective of this study was to investigate whether dark septate endophytes (DSEs) can increase plant drought tolerance in the context of vegetation concrete, which is a complex environment.MethodsThis study employed a controlled ...
Haoji Jia +14 more
doaj +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Study of growth of anti-erosion forest plantations on steep slopes of Arskiy district of RT [PDF]
BIO Web of ConferencesThe growth of anti-erosion forest plantations with pine, larch, birch and spruce on steep slopes of the Arsky district of the Republic of Tatarstan, 20 and 15 years old, was studied at two sites.
Singatullin Irek +3 more
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Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Degeneracy slopes, boundary slopes and exceptional surgery slopes
13 pages. ver.2, Corollary 2 is corrected, and a reference about Theorem 2 is added. ver.
openaire +2 more sources
, 2000 Fix a prime number p and choose, once and for all, an embedding of the algebraic closure of Q into Qp. Let k and N be integers, and suppose N is not divisible by p. If f is a modular form of weight k, level N, and trivial character which is an eigenform for the p-th Hecke operator Tp, we define the slope of f to be the p-adic valuation of the ...
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
On the Optimal Profile of a Slope
Soils and Foundations, 2007 The problem of determining the best profile for a c, φ soil slope is tackled, with reference to rigid rotational failure mechanisms. By means of limit analysis, upper bound values of collapse load are determined. A new mathematical function is derived to compute the external work made by the weight of a double spiral shaped soil region sliding away. It
Utili, S., Nova, R.
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source