Results 81 to 90 of about 2,508,126 (264)

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Exploring inconsistencies in environmental impact assessments of organic farming

Academia Environmental Sciences and Sustainability
Despite the growing popularity of organic farming, persistent questions surround its environmental effects. A 2017 meta-analysis suggested elevated acidification and eutrophication potentials per unit of agricultural production for organic ...
Hikaru Komatsu, Jeremy Rappleye
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Dark septate endophytes promote the growth of Cynodon dactylon under drought stress and enhance its potential for use in the ecological restoration of slopes

Frontiers in Plant Science
IntroductionThe objective of this study was to investigate whether dark septate endophytes (DSEs) can increase plant drought tolerance in the context of vegetation concrete, which is a complex environment.MethodsThis study employed a controlled ...
Haoji Jia, Haoji Jia, Qiming Geng, Mingyi Li, Mingyi Li, Ran Wang, Ran Wang, Fuhao Wang, Fuhao Wang, Yuxin Deng, Yuxin Deng, Wennian Xu, Wennian Xu, Daxiang Liu, Daxiang Liu   +14 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Differences and Influencing Factors of Soil Bacterial Communities Under Different Forest Types on the Southern Slope of the Qilian Mountains

Biology
Understanding the distribution patterns of soil bacterial community structure and diversity across different forest types is essential for elucidating the mechanisms underlying microbial community assembly and its ecological drivers, particularly under ...
Shuang Ji, Huichun Xie, Shaobo Du, Shaoxiong Zhang, Zhiqiang Dong, Hongye Li, Xunxun Qiu   +6 more
doaj   +1 more source

Study of growth of anti-erosion forest plantations on steep slopes of Arskiy district of RT [PDF]

BIO Web of Conferences
The growth of anti-erosion forest plantations with pine, larch, birch and spruce on steep slopes of the Arsky district of the Republic of Tatarstan, 20 and 15 years old, was studied at two sites.
Singatullin Irek, Yatmanova Nadezhda, Petrova Guzel, Chernov Vasily   +3 more
doaj   +1 more source

Two devices for analysis of nystagmus [PDF]

, 1969
Electromechanical Slope Computer /ESC/ and Electronic Summation Device /ESD/ facilitates rapid analysis of nystagmus records. The ESC reads out the slope and time of each nystagmus wave form. The ESD provides much faster analysis than the ESC.
Guedry, F. E., Jr., Turnipseed, G., Turnipseed, G. T.   +2 more
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Cooling slope casting to obtain thixotropic feedstock [PDF]

, 2007
Thixoforming, and related semi-solid processing routes for metallic alloys, require feedstock with a non-dendritic microstructure in the semi-solid state.
Atkinson, H.V., Cardoso Legoretta, E., Jones, H.   +2 more
core