Results 41 to 50 of about 220,258 (303)

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Analysis on slope stability by anchorage based on soil creep with flood effect

Heliyon
In order to analyze the adverse effect of flood affection on slope stability, the analytical expressions of buoyancy force and capillary force, hydrodynamic pressure and impact force, and scour erosion were proposed based on the aging characteristics of ...
Jun Wang, Lin Liu
doaj   +1 more source

Simple slope compensator for Ku-band applications.

, 1997
The present paper describes a simple circuital solution for a slope compensation function to be used in an amplification chain when it is necessary to recover for both fast ripple and slope variation occurred within the whole bandwidth. The circuit has been studied and developed mainly for Ku-Band applications and has been implemented in MMIC form ...
Feudale, M., Suriani, A.
openaire   +2 more sources

Effective inertial frame in an atom interferometric test of the equivalence principle

, 2017
In an ideal test of the equivalence principle, the test masses fall in a common inertial frame. A real experiment is affected by gravity gradients, which introduce systematic errors by coupling to initial kinematic differences between the test masses. We
Asenbaum, Peter, Hogan, Jason M., Kasevich, Mark A., Kovachy, Tim, Notermans, Remy, Overstreet, Chris   +5 more
core   +1 more source

Monitoring the Petermann Ice Island with TanDEM-X [PDF]

, 2012
This paper presents the processing of TanDEM-X acquisitions for the monitoring of the topography of the Petermann ice island. In this particular case the area under study is continuously moving and the acquisition geometry is changing, so the processing ...
Busche, Thomas, De Zan, Francesco, Eyssartier, Kevin, Garcia, Jose A., Krieger, Gerhard, Lopez-Dekker, Paco, Prats, Pau   +6 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Slope Compensation and Bifurcation in a DC-DC, Single-Input, Multiple-Output, CMOS Integrated Converter Under Current-Mode and Comparator-Based Hybrid Control

Journal of Low Power Electronics and Applications
Single-Input, Multi-Output (SIMO) converters present significant challenges when operated under current-mode control, due to their strongly non-linear dynamics and susceptibility to bifurcation phenomena. To mitigate the effects on the converter’s steady-
Mathieu Ginet, Eric Feltrin, Nicolas Jeanniot, Bruno Allard, Xuefang Lin-Shi   +4 more
doaj   +1 more source

Ossified Posterior Longitudinal Ligament Existing at an Intervertebral Level Limits Compensatory Mechanism of Cervical Lordosis after Muscle-Preserving Selective Laminectomy

Spine Surgery and Related Research, 2019
Introduction: As C7 slope increases, lordotic change of C2-C7 angle compensates for adjustments in cervical sagittal balance. However, ossification of the posterior longitudinal ligament (OPLL) may affect the compensatory mechanism of the cervical spine.
Satoshi Nori, Ryoma Aoyama, Ken Ninomiya, Satoshi Suzuki, Ukei Anazawa, Tateru Shiraishi   +5 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Breakdown of Kinetic Compensation Effect in Physical Desorption

, 2017
The kinetic compensation effect (KCE), observed in many fields of science, is the systematic variation in the apparent magnitudes of the Arrhenius parameters $E_a$, the energy of activation, and $\nu$, the preexponential factor, as a response to ...
Calbi, M. Mercedes, Silbert, Leonardo E., Zuniga-Hansen, Nayeli   +2 more
core   +1 more source