Results 41 to 50 of about 36,385 (261)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Ossified Posterior Longitudinal Ligament Existing at an Intervertebral Level Limits Compensatory Mechanism of Cervical Lordosis after Muscle-Preserving Selective Laminectomy

Spine Surgery and Related Research, 2019
Introduction: As C7 slope increases, lordotic change of C2-C7 angle compensates for adjustments in cervical sagittal balance. However, ossification of the posterior longitudinal ligament (OPLL) may affect the compensatory mechanism of the cervical spine.
Satoshi Nori, Ryoma Aoyama, Ken Ninomiya, Satoshi Suzuki, Ukei Anazawa, Tateru Shiraishi   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A New PWM Operational Scheme for MicroLED Displays Using Inverter and Dynamic SWEEP Signal Slope for Low Gray Level Expression

IEEE Access, 2023
In this paper, we present a novel pulse width modulation (PWM) operational scheme for micro-light-emitting-diode ( $\mu$ LED) displays using inverter and dynamic SWEEP signal slope.
Kyeong-Soo Kang, Ji-Hwan Park, Chanjin Park, Ji-Ho Lee, Soo-Yeon Lee   +4 more
doaj   +1 more source

Clustering Algorithm Reveals Dopamine‐Motor Mismatch in Cognitively Preserved Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore the relationship between dopaminergic denervation and motor impairment in two de novo Parkinson's disease (PD) cohorts. Methods n = 249 PD patients from Parkinson's Progression Markers Initiative (PPMI) and n = 84 from an external clinical cohort.
Rachele Malito, Chiara Meneghini, Alice Galli, Luca Gallo, Pierfrancesco Mitrotti, Paola Dimartino, Marianna Inglese, Cinzia Zatti, Alessandro Lupini, Andrea Pilotto, Alessandro Padovani, Micol Avenali, Enza Maria Valente, Cristina Tassorelli, Silvia P. Caminiti   +14 more
wiley   +1 more source

Tolerance Analysis Method Using the Ray Fan Slope for Performance Compensation of the Optical System

IEEE Access
Performance degradation due to tolerance inevitably occurs in the design and fabrication process of optical products. Previous studies have analyzed the effect of tolerance from different perspectives; however, none have presented a consistent solution ...
Donghun Han, Yong Joo JO, Jaemyung Ryu, Hojong Choi   +3 more
doaj   +1 more source

Methodological foundations of directional stability of a machine-tractor unit in sloping agriculture [PDF]

BIO Web of Conferences
The article describes a method for holding a tractor unit (MTA) on a slope when performing technological operations by changing the angles of the tractor wheels and the mounted machine. The variants of the MTA movement trajectories are considered, graphs
Tarasova Saria, Asmankin Evgeny, Ushakov Yuriy, Ivanov Pavel, Neufeld Elena, Rotova Victoria   +5 more
doaj   +1 more source

Normal‐Appearing White Matter Injury Mediates Chronic Deep Venous Hypoxia and Disease Progression in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To explore how cerebral hypoxia and Normal‐Appearing White Matter (NAWM) integrity affect MS lesion burden and clinical course. Methods Seventy‐nine MS patients, including 13 clinically isolated syndrome (CIS) patients and 66 relapsing–remitting multiple sclerosis (RRMS) patients, and 44 healthy controls (HCs) were recruited from ...
Xinli Wang, Huiying Wang, Zhizheng Zhuo, Ai Guo, Ke Lv, Decai Tian, Chao Chai, Yunyun Duan, Shuang Xia   +8 more
wiley   +1 more source

Method for improving performance of devices for adjustable reactive power compensation [PDF]

E3S Web of Conferences, 2019
The article presents a method for selecting the parameters of the current-voltage characteristics of adjustable reactive power compensation devices used at sectioning stations of railway sections electrified by alternating current with a voltage of 27.5 ...
Cheremisin Vasiliy, Nikonov Andrey
doaj   +1 more source