Results 61 to 70 of about 91,762 (301)

Evaluation of Slope Stability Considering the Preservation of the General Patrimonial Cemetery of Guayaquil, Ecuador

Geosciences, 2019
Inefficient blasting techniques and poor closure management of the old quarry that existed during the 1970s in the area of the actual General Patrimonial Cemetery of Guayaquil resulted in an almost vertical slope of approximately 50 m in height and an ...
Fernando Morante, Maribel Aguilar, Gonzalo Ramírez, Roberto Blanco, Paúl Carrión, Josué Briones, Edgar Berrezueta   +6 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Modelling flexible thrust performance for trajectory prediction applications in ATM [PDF]

, 2016
Reduced thrust operations are of widespread use nowadays due to their inherit benefits for engine conservation. Therefore, in order to enable realistic simulation of air traffic management (ATM) scenarios for purposes such as
Casado, Enrique, Cavadini, Laurent, López Leonés, Javier, Matamoros Cid, Ismael, Mouillet, Vincent, Nuic, Angela, Prats Menéndez, Xavier, Vilaplana, Miguel   +7 more
core  

Aesthetic preference for art emerges from a weighted integration over hierarchically structured visual features in the brain [PDF]

, 2020
It is an open question whether preferences for visual art can be lawfully predicted from the basic constituent elements of a visual image. Moreover, little is known about how such preferences are actually constructed in the brain.
Iigaya, Kiyohito, O'Doherty, John P., Tanwisuth, Koranis, Wahle, Iman A., Yi, Sanghyun   +4 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Stability Analysis and Failure Mechanisms of Open Pit Rock Slope

Journal of the Civil Engineering Forum, 2016
Rock mass in nature tend to be unideal, for it is heterogeneous, anisotropic and has discontinuity. The discontinuity makes anisotropic strength and stress in the rock mass, and also controls the changing of the elastic properties of rock mass.
Yahdi Azzuhry
doaj   +1 more source

Rock mass quality classification based on deep learning: A feasibility study for stacked autoencoders

Journal of Rock Mechanics and Geotechnical Engineering, 2023
Objective and accurate evaluation of rock mass quality classification is the prerequisite for reliable stability assessment. To develop a tool that can deliver quick and accurate evaluation of rock mass quality, a deep learning approach is developed ...
Danjie Sheng, Jin Yu, Fei Tan, Defu Tong, Tianjun Yan, Jiahe Lv   +5 more
doaj   +1 more source

Lecture notes on sediment transportation and channel stability [PDF]

, 1961
These notes have been prepared for a series of lectures on sediment transportation and channel stability given by the authors to a group of engineers and geologists of the U. S. Department of Agriculture assembled at Caltech on September 12-16,1960. The
Brooks, Norman H., Kennedy, John F. (John Fisher), Vanoni, Vito A.   +2 more
core   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source