Results 81 to 90 of about 91,762 (301)

Geotechnical evaluation of rock cut slopes using basic Rock Mass Rating (RMRbasic), Slope Mass Rating (SMR) and Kinematic Analysis along Islamabad Muzaffarabad Dual Carriageway (IMDC), Pakistan

, 2020
Present study focuses on the geotechnical evaluation of rock instability along Islamabad -Muzaffarabad Dual Carriageway (IMDC). Review of the recent literature helped devising the methodology and accordingly activities for field studies were planned.
Farooq, Salman, Akram, Main Sohail
openaire   +1 more source

Stability Analysis of Cut Slopes Using Continuous Slope Mass Rating and Kinematic Analysis in Rudraprayag District, Uttarakhand

Geomaterials, 2011
In mountain terrains of Himalaya, road and highway networks play a vital role in remote areas for transportation, public network and all kind of socio-economic activities. The stability of rock slopes along the roads and highways is a major concern in these hilly regions.
R. K. Umrao, R. Singh, M. Ahmad, T. N. Singh   +3 more
openaire   +2 more sources

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Application of various extensions of slope mass rating and kinematic analysis based factor of safety in the Lesser Himalayas

Discover Geoscience
The Himalayan mountain ranges are well-known for dynamic geological and geotechnical conditions and often experience slope failures caused by a variety of natural and anthropogenic factors.
Abdul Wadood Khan, Pirzada Mohammad Haris, Tariq Siddique, Md. Erfan Ali Mondal   +3 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

ROCKFALL HAZARD ASSESSMENT AND GEOLOGICAL-GEOTECHNICAL CHARACTERIZATION OF A ROCK SLOPE IN BR-356

Holos, 2020
The rockfall hazard assessment for roads is very important in geotechnical engineering business. As the process is very fast and complex, a hazard analysis is of fundamental importance for the adoption of preventive action plans and mitigation of ...
Denise de Fátima Santos da Silva, Allan Erlikhman Medeiros Santos   +1 more
doaj   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Empirical and numerical hill slope health evaluation at Malling Nala, NH-505, Himachal Pradesh, India

International Journal of Geo-Engineering
Slope failures and rock mass movements are continuous geomorphic processes, particularly in a dynamically charged terrane like the Himalaya. Thus, failures emanating from weak geology, hydrogeology and anthropogenic disturbances are aplenty.
Md Alquamar Azad, Ashutosh Kainthola, Yewuhalashet Fissha, Gaurav Kushwaha, Vikas Yadav, T. N. Singh   +5 more
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Intelligent characterization of discontinuities and heterogeneity evaluation of potential hazard sources in high-steep rock slope by TLS-UAV technology

Journal of Rock Mechanics and Geotechnical Engineering
The identification of rock mass hazard sources is fundamental for preventing rockfall and landslide disasters in mountainous regions, with rock mass structural characteristics playing a vital role in hazard assessment.
Changqing Liu, Han Bao, Tianyi Wang, Jingfeng Zhang, Hengxing Lan, Shengwen Qi, Wei Yuan, Shunichi Koshimura   +7 more
doaj   +1 more source