Results 51 to 60 of about 831,958 (281)

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Evaluation of Xiashu loess slope stability in Zhenjiang area using different methods

open access: yesZhongguo dizhi zaihai yu fangzhi xuebao, 2021
Slope instability is the result of the continuous evolution of the interaction of geological environment conditions in a certain area, so many factors should be considered when evaluating the stability of a slope. In this paper, the influence factors and
Jingjing QU   +4 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Geometry and stability of tautological bundles on Hilbert schemes of points

open access: yes, 2015
The purpose of this paper is to explore the geometry and establish the slope stability of tautological vector bundles on Hilbert schemes of points on smooth surfaces. By establishing stability in general we complete a series of results of Schlickewei and
Stapleton, David
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

A Novel Attention-Based Generalized Efficient Layer Aggregation Network for Landslide Detection from Satellite Data in the Higher Himalayas, Nepal

open access: yesRemote Sensing
Landslide event detection poses a significant challenge in the remote sensing community, especially with the advancements in computer vision technology.
Naveen Chandra   +3 more
doaj   +1 more source

Matlab parallel codes for 3D slope stability benchmarks [PDF]

open access: yes, 2017
This contribution is focused on a description of implementation details for solver related to the slope stability benchmarks in 3D. Such problems are formulated by the standard elastoplastic models containing the Mohr-Coulomb yield criterion and by the ...
Cermak, Martin   +2 more
core  

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Landslide topology uncovers failure movements

open access: yesNature Communications
The death toll and monetary damages from landslides continue to rise despite advancements in predictive modeling. These models’ performances are limited as landslide databases used in developing them often miss crucial information, e.g., underlying ...
Kushanav Bhuyan   +6 more
doaj   +1 more source

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