Results 51 to 60 of about 2,817,058 (256)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Effect of the Suction on the Stability of a Silty Sand Slope [PDF]

open access: yes, 2019
This paper presents a revision of some of the models that have been proposed to estimate the strength of unsaturated soils. The theoretical results obtained from these models are compared with the experimental results of controlled suction triaxial tests
Mora-Ortiz, R.S., Slope, Effect
core  

Enhancing landslide detection in Western Ghats of Kerala, India with deep learning and Explainable AI

open access: yesScientific Reports
The Western Ghats in Kerala, India, have witnessed a significant rise in landslide occurrences in recent years. More recently in 2024, catastrophic landslides in Wayanad district claimed 336 lives, with 78 people reported missing, underscoring the urgent
Abhilash Sreekumar   +3 more
doaj   +1 more source

Influence of the Slope Shape on Seismic Stability of a Slope

open access: yesAdvances in Civil Engineering, 2020
The slope shape is one of the most intuitive factors affecting the seismic stability of a slope. However, current research on this subject is mainly focused on statistical analysis and seismic response law, and the influence on seismic stability ...
Zhaopeng Zhang, Chaoyu Chang, Zhiyi Zhao
doaj   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

Slope stability analysis by using multiple shear strength model [PDF]

open access: yes, 2013
Rainfall-induced landslide is a condition where rain water infiltrates into slope causing additional load and loss of shear strength of soil mass and eventually triggers slope failure. It is difficult to determine by applying conventional slope stability
Lim, Kim Ong
core  

Study on slope stability under different weak layer replacement parameters in open-pit mine

open access: yesMeikuang Anquan, 2023
Improving slope stability is one of the important ways to ensure the safe operation of open pit coal mines and improve the resource recovery rate. Through Bishop’s analysis, the derivation of the expression of slope stability coefficient of replacement ...
TU Lixiao, TIAN Ya, WANG Zhile, ZHOU Wei, CAI Qingxiang, LU Xiang
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Three-dimensional limit equilibrium method for rock slopes by constructing normal stress distribution over sliding surface and its application

open access: yesYantu gongcheng xuebao
The researches on the three-dimensional stability of rock slopes are of important theoretical significance and engineering application prospect. The conventional equivalent Mohr-Coulomb strength parameters used to analyze the stability of rock slopes ...
LU Kunlin 1, MEI Yifan 1, WANG Linfei 2, JIA Senlin 1, QIN Tao 1, ZHU Dayong 3
doaj   +1 more source

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