Results 51 to 60 of about 213,923 (293)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

A Novel Attention-Based Generalized Efficient Layer Aggregation Network for Landslide Detection from Satellite Data in the Higher Himalayas, Nepal

Remote Sensing
Landslide event detection poses a significant challenge in the remote sensing community, especially with the advancements in computer vision technology.
Naveen Chandra, Himadri Vaidya, Suraj Sawant, Sansar Raj Meena   +3 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Landslide topology uncovers failure movements

Nature Communications
The death toll and monetary damages from landslides continue to rise despite advancements in predictive modeling. These models’ performances are limited as landslide databases used in developing them often miss crucial information, e.g., underlying ...
Kushanav Bhuyan, Kamal Rana, Joaquin V. Ferrer, Fabrice Cotton, Ugur Ozturk, Filippo Catani, Nishant Malik   +6 more
doaj   +1 more source

Evaluation of the Reinforcement Performance of Loess Slopes Affected by Rainfall Infiltration

Geofluids, 2022
The instability disaster of slope engineering is the third largest geological disaster after earthquake and debris flow, and rainfall is an important factor affecting the stability of slopes.
Yongdong Yang, Hai Liu, Hongfei Li, Shengrui Su, Wanfeng Liu, Yunxiu Dong, Dong Wang   +6 more
doaj   +1 more source

Upper bound analysis of the anti-seismic stability of slopes considering the effect of the intermediate principal stress

Frontiers in Earth Science, 2023
Considering the intermediate principal stress effect of soils, the unified strength theory was applied to correct the shear strength index of soils.
Biao Zhang, Quanli Sun
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

An integrated approach for rockfall analysis with drapery systems

, 2013
The rockfall hazard in mining environments needs to be rigorously managed in order to ensure safe mining operations, in particular when designing portal entries for punch longwalls. The installation of drapery systems is a common practice to mitigate the
Scott Sloan, Klaus Thoeni, Thoeni, Klaus, Giacomini, Anna, John Carter, Cédric Lambert, Anna Giacomini, Lambert, Cedric, Carter, John P. (R18260), Sloan, Scott W.   +9 more
core   +1 more source

LSDSAM: Harnessing Visual Foundation Model and Enhanced Transfer Learning Toward Practical Landslide Detection in Few-Shot Scenarios

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
Landslides occur frequently in mountainous regions worldwide, emergency management and risk analysis urgently need automated, accurate landslide detection (LSD) techniques.
Zijin Fu, Fawu Wang, Zihan Tu, Xingliang Peng, Guanting Liu, Filippo Catani   +5 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source