Results 71 to 80 of about 213,923 (293)

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Modeling the evolution of natural cliffs subject to weathering. 1, Limit analysis approach [PDF]

, 2011
Retrogressive landsliding evolution of natural slopes subjected to weathering has been modeled by assuming Mohr-Coulomb material behavior and by using an analytical method.
G. B. Crosta, Crosta, Giovanni B., Utili, Stefano, S. Utili   +3 more
core   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Coupled effects of earthquake and rainfall on landslide susceptibility in non-tropical coastal areas: assessing governing mechanisms and innovative slope protection strategy

Discover Civil Engineering
Despite extensive research on landslides globally, there is a notable knowledge gap on mechanisms influenced by combined rainfall and earthquake events to induce landslides in non-tropical coastal areas, and how to mitigate such failures.
Prabhakar Khadka, Oladoyin Kolawole, Andrew C. Amenuvor, Mawuko L. Y. Ankah   +3 more
doaj   +1 more source

Three-dimensional limit equilibrium method for rock slopes by constructing normal stress distribution over sliding surface and its application

Yantu gongcheng xuebao
The researches on the three-dimensional stability of rock slopes are of important theoretical significance and engineering application prospect. The conventional equivalent Mohr-Coulomb strength parameters used to analyze the stability of rock slopes ...
LU Kunlin 1, MEI Yifan 1, WANG Linfei 2, JIA Senlin 1, QIN Tao 1, ZHU Dayong 3
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Seepage-damage coupling study of the stability of water-filled dump slope

, 2014
The stability of water-filled dump slope has been one significant geotechnical engineering problem that needs to be urgently resolved. The coupling effects of seepage and damage on the dump slope are critically important for stability analysis.
吕祥锋, Wang, JG, 王振伟, Lv, XF (reprint author), Chinese Acad Sci, Inst Mech, 15 North Fourth Ring Rd, Beijing 100190, Peoples R China.   +3 more
core   +1 more source

EVALUATION OF SLOPE STABILITY PROBLEMS

Jurnal Pensil
Expansive soils are highly susceptible to volumetric changes due to moisture fluctuations, which can significantly affect the stability and durability of structures.
Bayu Wintoro, Abi Maulana Hakim, Aozora Insan Kamil, Amirah Zakiyyah   +3 more
doaj   +1 more source