Results 91 to 100 of about 2,817,058 (256)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
, 2013 Joint roughness coefficient (JRC) is one of the important parameters to determine shear strength of joints. JRC values are generally measured using profile gauges and estimated by comparing the surface profiles with typical roughness profiles. Therefore,
Poropat, G. +2 more
core
Influence factors analysis of soil nailing support slope
Shuili Shuiyun Gongcheng Xuebao, 2018 In order to analyze the influences of the soil nailing parameters on the stability of the slope, a slope model with an angle of 60° was established for indoor geotechnical testing.
LI Guoqing +3 more
doaj +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
, 2007 this paper, two methods are developed for determining the global slope of the word image. The first method estimates the slope by finding the minimum entropy in the vertical projection histograms, whereas the second method determines the slope from the ...
Slope Correction
core
Stability analysis of water-filled dump slope under the couple effect of seepage and damage
, 2012 The stability problem of water-filled dump slope becomes one of the geotechnical engineering problems needed to be resolved. Especially, the couple effect of seepage and damage has a great influence on the dump slope.
吕祥锋 +3 more
core +2 more sources
Scientific ReportsIn the stability analysis of loess fill slope, the fissure nature of loess is often ignored, which makes the stability calculation of fill slope too conservative.
Zhuangfu Zhao +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Slope stability and sheet pile and contiguous bored pile walls
, 2012 Before any construction of retaining structures it is important to understand the behavior of the soil and the characteristic of the failure modes involved.
Adhami, Behnam +5 more
core