Results 91 to 100 of about 213,923 (293)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Three dimensional slope stability analyses for natural and manmade slopes
, 2011 Item released from any restrictions by Sarah Shreeves (sshreeve@illinois.edu) on 2013-05-26T10:00:17ZSlope stability analyses in practice mostly rely on limit equilibrium (LE) procedures rather than finite element (FE) or finite difference (FD ...
Akhtar, Kamran
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Advances in Civil Engineering, 2019 Slope stability analysis is the most important problem in slope engineering design and construction. Open-pit slope often spans several strata, many of which are relatively weak. There may be faults and weak layers across the whole rock.
Yang Li +3 more
doaj +1 more source
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy +10 more
wiley +1 more source
, 2013 Joint roughness coefficient (JRC) is one of the important parameters to determine shear strength of joints. JRC values are generally measured using profile gauges and estimated by comparing the surface profiles with typical roughness profiles. Therefore,
Poropat, G. +2 more
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Rock cut slope stability evaluation of the Crocker formation along Jalan UMS, Kota Kinabalu, Sabah [PDF]
, 2012 The aim of this paper is to present the result of an evaluation of the cut rock slope stability of the Crocker Formation along Jalan UMS, Kota Kinabalu, Sabah.
Ismail Abd Rahim +3 more
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Evaluation of the stability of a highway slope through numerical modeling [PDF]
, 2017 Mass movement in natural slopes can cause great material and human loss for society. In this context, stability analyses become quite complex since there are a large number of uncertainties involved in the interpretation of the problem.
Marques, Gabriel Steluti +5 more
core +1 more source