Results 111 to 120 of about 213,923 (293)
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Slope stability and sheet pile and contiguous bored pile walls
, 2012 Before any construction of retaining structures it is important to understand the behavior of the soil and the characteristic of the failure modes involved.
Adhami, Behnam +5 more
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Modelling shallow landslides: the importance of hydrological controls and lateral reinforcement [PDF]
, 2008 Shallow landslides are important as geomorphic agents of erosion, sources of catchment sediment and potential hazards to life and infrastructure. The importance of these mass movements is difficult to define using solely field- based approaches because ...
Milledge, David Graham
core
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
A Study on Stabilization Sandy Soil Slope
, 1990 P(論文)The vegetation method has been widely used in order to control the erosion on slope surface. In sandy soil slopes, however, the vegetation often cannot be sufficiently carried out, because in such soils, erosion occurs within ashort period after ...
41993, 富田, 武満 /, 41912
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FEBS Open Bio, EarlyView.ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Modelling rock slope behaviour and evolution with reference to Northern Spain and Southern Jordan [PDF]
, 2004 The geomorphological behaviour of steep jointed rock slopes has been studied using distinct element computer models. In order to model steep slopes effectively, methodologies need to be combined from the studies of environmental modellers ...
Nelis, Simon Brett
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Screening and epitope characterization of Nidogen‐2‐specific nanobodies
FEBS Open Bio, EarlyView.Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen +9 more
wiley +1 more source