Results 101 to 110 of about 213,923 (293)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Chart-based slope stability assessment using the slope shape influence factor

Results in Engineering
In order to quickly assess the stability of slopes from the perspective of slope size, this study first conducts Morgenstern-Price method to analyze the influence of slope size parameters on slope stability and scale of the sliding body.
Shunchuan Wu, Shigui Huang, Longqiang Han, Chao Wang, Min Ren, Haokai Shen   +5 more
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

3D finite element back analysis of a large rockslope failure on the East wall of the LAB Chrysotile Mine in Canada

, 2018
A major mining slope failure occurred in July 2012 on the East wall of the LAB Chrysotile mine in Canada. The failure zone was 1000 m x 100 m, with a mobilized volume of 25 hm3.
Grenon, Martin, Caudal, Philippe
core  

Stability analysis of loess fill slope supported by frame prestressed anchors considering tensile strength cut-off

Scientific Reports
In the stability analysis of loess fill slope, the fissure nature of loess is often ignored, which makes the stability calculation of fill slope too conservative.
Zhuangfu Zhao, Yanpeng Zhu, Hongjie Hou, Lian Li   +3 more
doaj   +1 more source

Global landslide mapping using U-Net architecture with diverse backbones across multi-regional and multi-sensor remote sensing datasets

Frontiers in Earth Science
Landslides remain a constant hazard to societies in hilly regions worldwide, necessitating accurate and scalable detection techniques. In this study, we assess the performance of cutting-edge deep learning architecture, specifically U-Net, combined with ...
Naveen Chandra, Naveen Chandra, Himadri Vaidya, Himadri Vaidya, Kumar Abhinav, Sansar Raj Meena, Sansar Raj Meena   +6 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

A prototype of a self-assembly slope-stability scanner for small slopes

, 2019
Landslide is a frequent hazard, which causes thousands of fatalities annually worldwide. However, the incidents are predictable if there is appropriate monitoring equipment.
To, Peter
core  

Slope instability along the north-west coast in Malta [PDF]

, 2001
Mass movement processes operating along the coastal zone, north of the Great Fault are examined. Slides fall under three main categories. Rotational slides and translational slides occur in the Upper Coralline Limestone whereas mudslides are found where ...
Magri, Odette
core