Results 81 to 90 of about 831,958 (281)
New hydroacoustic and core data reveal sediment transport patterns off Uruguay [PDF]
, 2010 Submarine landslides cause slope instabilities and might damage sea-floor infrastructure or even generate tsunami waves. Therefore it is of major importance to understand all processes related to gravity-driven mass wasting and slope stability at ...
Anasetti, Andrea +6 more
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
EVALUATION OF SLOPE STABILITY PROBLEMS
Jurnal PensilExpansive soils are highly susceptible to volumetric changes due to moisture fluctuations, which can significantly affect the stability and durability of structures.
Bayu Wintoro +3 more
doaj +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon +9 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Effect of intermediate principal stress on the stability of slopes [PDF]
Archives of Civil EngineeringThe intermediate principal stress (σ2 ) effect is a mechanical property inherent in many rock and soil materials. However, the effect of σ2 is often ignored in slope stability analyses, and its impact on slope stability is seldom investigated.
Zongyuan Ma, Lei Liu
doaj +1 more source
Determination of jet fuel thermal deposit rate using a modified JFTOT [PDF]
, 1980 Three fuels having different breakpoint temperatures were studied in the modified jet fuel thermal oxidation tester. The lower stability fuel with a breakpoint of 240 C was first stressed at a constant temperature.
Delfosse, R. J., Nowack, C. J.
core +1 more source
, 2008 We present a unified approach for qualitative and quantitative analysis of stability and instability dynamics of positive bright solitons in multi-dimensional focusing nonlinear media with a potential (lattice), which can be periodic, periodic with ...
B. Crosignani +13 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source