Results 121 to 130 of about 73,922 (300)

Modelling of Anisotropy in Slope Stability Problems - A study about slope stability in Göta Älv valley [PDF]

, 2020
The purpose of this Master’s thesis is to analyse the effects of considerations for anisotropy in slope stability problems using two different calculation models.
Svensson, Andrea
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

HYDROLOGICAL AND STABILITY MODELLING OF INITIAL LANDSLIDES TRIGGERING DEBRIS FLOWS IN ASH-FALL DEPOSITS COVERING HILLSLOPES SURROUNDING SOMMA-VESUVIUS (SOUTHERN ITALY). [PDF]

, 2010
Rainfall-induced debris flows involving ash-fall pyroclastic deposits covering steep mountain slopes that surround the Somma-Vesuvius volcano, are natural events representing the main cause of risk for urban settlements located at footslopes.
Napolitano, Elisabetta
core  

Predicting and evaluating slope stability in permafrost regions of the central Qinghai‒Tibetan Plateau

Advances in Climate Change Research
Thermokarst landslides have frequently occurred in the central Qinghai‒Tibetan Plateau (QTP), endangering infrastructure and the environment. However, there have been no adequate methods to predict thermokarst landslides until now.
Fei Wang, Bo Huang, Mikhail Zhelezniak, Xiao-Ying Li, Alexander Zhirkov, Qi-Hao Yu, Zhi Wen   +6 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Slope stability analysis and road safety evaluation [PDF]

, 2012
This master thesis focuse on natural slope and embankment slope stability analysis with the Limit Equilibrium Method computer program Slope/W and the Finite Element Method computer program Plaxis 2D and a comparison of the analyzed result.
RAHMAN
core