Results 101 to 110 of about 7,834,713 (261)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

3D finite element back analysis of a large rockslope failure on the East wall of the LAB Chrysotile Mine in Canada

, 2018
A major mining slope failure occurred in July 2012 on the East wall of the LAB Chrysotile mine in Canada. The failure zone was 1000 m x 100 m, with a mobilized volume of 25 hm3.
Grenon, Martin, Caudal, Philippe
core  

A prototype of a self-assembly slope-stability scanner for small slopes

, 2019
Landslide is a frequent hazard, which causes thousands of fatalities annually worldwide. However, the incidents are predictable if there is appropriate monitoring equipment.
To, Peter
core   +1 more source

Study on the initiation mechanism and motion characteristics of the Daguangbao landslide and the slope stability evaluation method

Frontiers in Built Environment
Landslide triggered by earthquake has always been the hotspot due to its large scale, unique genesis, and complex kinematic processes. In this paper, the Daguangbao landslide in the 2008 Wenchuan Ms8.0 earthquake is selected as the research object.
Dejie Yu, Dejie Yu, Lei Liu, Lei Liu, Yue Ding, Fan Yang, Xiangyu Zhang   +6 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

The determination of joint roughness coefficient using three-dimensional models for slope stability analysis

, 2013
Joint roughness coefficient (JRC) is one of the important parameters to determine shear strength of joints. JRC values are generally measured using profile gauges and estimated by comparing the surface profiles with typical roughness profiles. Therefore,
Poropat, G., Gratchev, Ivan, Kim, Dong Hyun   +2 more
core  

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Predicting and evaluating slope stability in permafrost regions of the central Qinghai‒Tibetan Plateau

Advances in Climate Change Research
Thermokarst landslides have frequently occurred in the central Qinghai‒Tibetan Plateau (QTP), endangering infrastructure and the environment. However, there have been no adequate methods to predict thermokarst landslides until now.
Fei Wang, Bo Huang, Mikhail Zhelezniak, Xiao-Ying Li, Alexander Zhirkov, Qi-Hao Yu, Zhi Wen   +6 more
doaj   +1 more source