Results 91 to 100 of about 73,922 (300)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Engineering geological conditions and slope stability evaluation of aukštakalnio g. 16, utenaterritory. [PDF]

open access: yes, 2021
Work theme – engineering geological conditions and slope stability evaluation of Aukštakalnio g. 16, Utena territory. The main aim of work: evaluate engineering geological conditions of territory, fulfil data analysis and evaluate slope stability.
Jonytis, Povilas,
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Stability of rock slope and fuzzy comprehensive evaluation method [PDF]

open access: yes, 1999
In order to get more practical uncertain results, according to different stability states, common slopes are devided into five kinds. Every kind of slopes is assigned a value of certain classified standard.
Lee, PKK   +4 more
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Stability Evaluation of Slope Based on Global Sensitivity Analysis

open access: yesComplexity
The uncertainty of parameters will have a significant impact on slope stability, where sensitivity analysis is a commonly used method in uncertainty research. However, traditional sensitivity analysis method costs much computation time. When calculating the sensitivity index of one parameter, all other parameters are taken as fixed values, and the ...
Zhaoxia Xu   +3 more
openaire   +2 more sources

Slope Stability Evaluation of Geosynthetic Reinforced Soil

open access: yesInternational Journal of Recent Technology and Engineering (IJRTE), 2019
The slippery of natural slope is sometimes ruled by combination of soil parameters and earthquake characteristics. Geotextiles could be a reinforcing materials and an application in numerous areas still as in geotechnical application to supply additional lateral restraint and forestall the high rise hill from failure.
Sarath Babu M*   +2 more
openaire   +1 more source

Análise de estabilidade bi e tridimensional de talude estabilizado em solo grampeado [PDF]

open access: yes, 2006
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia Civil.O emprego da técnica do reforço de solos para a estabilização de taludes, naturais ou não, através do grampeamento do solo,
Oliveira, Vanessa Scoz
core  

Techniques to Evaluate and Remediate the Slope Stability in Overconsolidated Clay

open access: yes, 2020
In this chapter, the origin and remediation of an important sliding in the overconsolidated Boom Clay in Kruibeke (Belgium) is discussed. Local and environmental factors caused an unstable slope about 30 m deep, A larger sensitivity to erosion resulted finally in the instability of the slope.
openaire   +3 more sources

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