Results 91 to 100 of about 7,834,713 (261)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Extreme rainfall for slope stability evaluation
, 2009 : Slopes in tropical region are prone to frequent rainfall-induced failures; hence the evaluation of slope stability has to consider the rainfall characteristics and other factors related to rainfall infiltration. This paper demonstrates the results of
Nurly, Gofar
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Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Geomatics, Natural Hazards & Risk, 2018 To systematically evaluate the risk grade of stability of expansive soil slope during construction, the recognition model is established by using the fuzzy recognition theory and the analytic hierarchy process (AHP).
Jian Zhang, Peng He, Jie Xiao, Fei Xu
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Comprehensive Stability Evaluation of Rock Slope Using the Cloud Model-Based Approach
, 2014 International audienceThis article presents the cloud model-based approach for comprehensive stability evaluation of complicated rock slopes of hydroelectric stations in mountainous area.
Liu, Zaobao +3 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
A Study on Stabilization Sandy Soil Slope [PDF]
, 1990 P(論文)The vegetation method has been widely used in order to control the erosion on slope surface. In sandy soil slopes, however, the vegetation often cannot be sufficiently carried out, because in such soils, erosion occurs within ashort period after ...
41993, 富田, 武満 /, 41912
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Modelling shallow landslides: the importance of hydrological controls and lateral reinforcement [PDF]
, 2008 Shallow landslides are important as geomorphic agents of erosion, sources of catchment sediment and potential hazards to life and infrastructure. The importance of these mass movements is difficult to define using solely field- based approaches because ...
Milledge, David Graham
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