Results 81 to 90 of about 7,834,713 (261)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Fuzzy Comprehensive Evaluation Method and Application of Slope Stability

open access: yes, 2011
Establish a nonlinear membership function of slope stability taking the case of six different sliding blocks on a typical slope and do a second class fuzzy comprehensive evaluation on the determinate membership.
Zi Jian Wang, Li Ming Wu
core   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

Discussion of Evaluation Index in Probabilistic Slope Stability Analysis

open access: yes, 2011
Probabilistic slope stability analyses have been adopted in study and geotechnical practice. But there are many misconceptions in the literature. One of these is the evaluation index of slope.
Zhen Jun Wu, Wei Wang
core   +1 more source

Slope stability evaluation using backpropagation neural networks and multivariate adaptive regression splines

open access: yesOpen Geosciences, 2020
Slope stability assessment is a critical concern in construction projects. This study explores the use of multivariate adaptive regression splines (MARS) to capture the intrinsic nonlinear and multidimensional relationship among the parameters that are ...
Liao Zhihao, Liao Zhiwei
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Extreme rainfall analysis for slope stability evaluation

open access: yes, 2009
Slopes in tropical region are prone to frequent rainfall-induced failures; hence the evaluation of slope stability has to consider the rainfall characteristics and other factors related to rainfall infiltration.
Gofar, Nurly   +2 more
core  

Design charts for the stability analysis of unsaturated soil slopes [PDF]

open access: yes, 2009
Simple limit equilibrium analyses can be performed to determine the Factor of Safety (FOS) against slope failure of unsaturated soil slopes. However, many of the input parameters needed for these analyses are highly variable, and the FOS value obtained ...
Gavin, Kenneth   +3 more
core   +1 more source

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