Results 61 to 70 of about 7,834,713 (261)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
An evaluation method of open-pit slope stability based on Poset theory
Geomechanics and Geophysics for Geo-Energy and Geo-ResourcesTo achieve an objective and reasonable judgment on slope stability, the partially ordered set (Poset) theory is applied to the slope stability evaluation against the engineering background of an open pit slope.
Juyu Jiang +5 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Effect of the Suction on the Stability of a Silty Sand Slope [PDF]
, 2019 This paper presents a revision of some of the models that have been proposed to estimate the strength of unsaturated soils. The theoretical results obtained from these models are compared with the experimental results of controlled suction triaxial tests
Mora-Ortiz, R.S., Slope, Effect
core
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Slope stability analysis by using multiple shear strength model [PDF]
, 2013 Rainfall-induced landslide is a condition where rain water infiltrates into slope causing additional load and loss of shear strength of soil mass and eventually triggers slope failure. It is difficult to determine by applying conventional slope stability
Lim, Kim Ong
core
Slope stability evaluation based on set pair cloud model
, 2019 When the set pair analysis is applied to evaluate slope stability, the connection degree is usually decided by linear function, which can\u27t reflect the actual conditions of the engineering project objectively and comprehensively and neglect the system
Shan, ZHANG, Jianye, YAO, Guoqiang, HAO
core +1 more source
Study on cutting high-slope stability evaluation based on fuzzy comprehensive evaluation method and numerical simulation [PDF]
, 2017 Usijecanje velike kosine je složeni nelinearni sustav koji je slučajan, nejasan i promjenljiv. Procjena njene stabilnosti, uzevši u obzir i kvalitativne i kvantitativne mogućnosti, bitna je u procjeni izbjegavanja velike nesreće.
Yan, Xiaodong, Xiaodong Yan
core +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source