Results 41 to 50 of about 71,432 (265)

Association Between Dinutuximab Beta Exposure and Post‐End‐of‐Treatment Survival in Neuroblastoma: A Weighted Patient‐Level Analysis of Three Clinical Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Objectives The association between exposure to dinutuximab beta (DB) and event‐free survival (EFS) or overall survival (OS) of neuroblastoma patients was assessed using data collected during three clinical trials (five cohorts). Methods A systematic review (March 2026) was conducted to identify relevant studies (prospective; registered DB ...
Przemysław Holko, Holger N. Lode, Alberto Garaventa, Carla Manzitti, Roberto Luksch, Dominique Valteau‐Couanet, Marion Gambart, John Anderson, Juliet Gray, Adela Canete, Lucas Moreno, Aleksandra Wieczorek, Cormac Owens, Shifra Ash, Isaac Yaniv, Genevieve Laureys, Hans Loibner, Katarzyna Śladowska, Ruth Ladenstein, Paweł Kawalec   +19 more
wiley   +1 more source

Performance Evaluation and Engineering Verification of Machine Learning Based Prediction Models for Slope Stability

Applied Sciences, 2022
Stability evaluation of geotechnical engineering slopes is of great significance for the risk control and safe operation of many engineering. Machine learning methods can effectively establish the potential relationship between geological features and ...
Gexue Bai, Yunlong Hou, Baofeng Wan, Ning An, Yihao Yan, Zheng Tang, Mingchun Yan, Yihan Zhang, Daoyuan Sun   +8 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

A New Method for Slope Risk Stability Assessment: Combined Weighting and Improved Cloud Matter‐Element Model

Engineering Reports
In order to accurately evaluate the grade of slope stability and reduce the risk of geological disasters, a comprehensive evaluation method of slope stability based on game theory and finite interval cloud matter element model is proposed. Firstly, based
Wan‐Rui Hu, Heng Liu, Xing‐Tao Zhou, Bo Wei, Ceng Shang, Peng Guan   +5 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Open-pit mine slopes stability analysis based on analytic hierarchy process-fuzzy comprehensive evaluation model

Zhongguo dizhi zaihai yu fangzhi xuebao
The bench slope within an open-pit coal mine plays an important supporting role for coal resource production and transportation. The stability evaluation of the slope is of great significance in guiding continuous mining operations within the mine.
Zhiguo LI, Tao XU, Yongjie LIU, Lichun ZHAO, Yongchao XU, Tianhong YANG, Xiaobin ZHENG   +6 more
doaj   +1 more source

Image-Data-Driven Slope Stability Analysis for Preventing Landslides Using Deep Learning

IEEE Access, 2021
Landslides account for approximately 5% of natural disasters resulting in significant socio-economic impacts. As a major infrastructure issue, slope stability has been traditionally analyzed with multiple deterministic and probabilistic methods to
Behnam Azmoon, Aynaz Biniyaz, Zhen Liu, Ye Sun   +3 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source