Results 51 to 60 of about 7,834,713 (261)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Three dimensional slope stability analyses for natural and manmade slopes [PDF]

open access: yes, 2011
Item released from any restrictions by Sarah Shreeves (sshreeve@illinois.edu) on 2013-05-26T10:00:17ZSlope stability analyses in practice mostly rely on limit equilibrium (LE) procedures rather than finite element (FE) or finite difference (FD ...
Akhtar, Kamran
core  

Evaluation of Slope Stability Based on Fuzzy Mathematics with Combination Weighting Method of Game Theory

open access: yesRenmin Zhujiang, 2021
In order to accurately evaluate the stability of the slope and reduce the risk of landslides,taking the Jiangjiatang slope project in Xingshan,Hubei as an example,this paper selects four first-level indexes namely topography and geomorphology,geological ...
ZHOU Jintao
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Stability Evaluation of Rock Slope–Anchoring Systems Based on Catastrophe Theory

open access: yesApplied Sciences
With the rapid development of China’s economy, the number and scale of infrastructure projects in energy, water conservancy, and transportation have expanded significantly.
Peng Xia   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Analysis on deformation characteristics of a cutting high bedding rock slope with multiple weak layers based on physical model tests

open access: yesZhongguo dizhi zaihai yu fangzhi xuebao, 2022
The excavated slope with multi-layer weak interlayer has the characteristics of complex slope structure and difficult stability evaluation and treatment.
Chenglin MU   +3 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

open access: yesFEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg   +14 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

open access: yesFEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt   +8 more
wiley   +1 more source

Evaluation of Live Cuttings Effect on Slope Stability

open access: yesFloresta e Ambiente, 2018
The aim of this work was to evaluate the development of shrub live cuttings and their effect on slope stability. Vertical in situ pullout tests and measurements of Phyllanthus sellowianus shoots and roots of 2, 4, 6, 8, 10 and 14 months old were ...
Charles Rodrigo Belmonte Maffra   +3 more
doaj   +1 more source

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