Results 131 to 140 of about 127,937 (288)

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

open access: yesFEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero   +5 more
wiley   +1 more source

Slow Fashion Movement: An Exploratory Study

open access: yes, 2013
The retail industry currently is dominated by fast-fashion spurring overconsumption where consumers buy more than they need, leading to fashion waste.
Shephard, Arlesa
core  

Moda e sustentabilidade, um olhar sobre o Fast Fashion, Slow Design e Slow Fashion [PDF]

open access: yes, 2018
A indústria do vestuário está dentre as mais poluentes no mundo, apresentando ao longo de seu ciclo impactos químicos e sociais. Tendo em vista esses impactos, o presente artigo objetiva expor alguns sistemas de produção de moda presentes na atualidade ...
Onyszko, Maiara Paula Woievoda
core  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

open access: yesFEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta   +7 more
wiley   +1 more source

The gleaning guide: venturing in redirective fashion [PDF]

open access: yes, 2013
: Gleaning, when adopted as an attitude and an action, is useful in seeing and utilising the value in what has been cast aside. This is gleaning through the physical collection of what is left behind, alongside gleaning that is slow, incremental and ...
Tania Splawa-Neyman
core  

Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells

open access: yesFEBS Open Bio, EarlyView.
To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai   +8 more
wiley   +1 more source

Challenging perceptions of fast and slow fashion: 1960s paper dresses and the concept of disposable garments

open access: yes, 2023
In this talk, Liz and Hannah explored how historic models of fashion and textile manufacture can inspire new sustainable models for both manufacture and consumption.
Tregenza, Liz, Auerbach George, Hannah
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Slow fashion em Portugal: uma abordagem exploratória [PDF]

open access: yes, 2019
A presente dissertação tem como o objetivo de compreender o conhecimento dos consumidores acerca do slow fashion em Portugal; compreender o conhecimento dos consumidores quanto aos problemas ambientais na indústria do vestuário; compreender as suas ...
Gomes, Yelizaveta Maznyeva
core  

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

open access: yesFEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose   +9 more
wiley   +1 more source

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