Results 101 to 110 of about 2,387,223 (285)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Slow light with interleaved p-n junction to enhance performance of integrated Mach-Zehnder silicon modulators

Nanophotonics, 2019
Slow light is a very important concept in nanophotonics, especially in the context of photonic crystals. In this work, we apply our previous design of band-edge slow light in silicon waveguide gratings [M. Passoni et al, Opt.
Passoni Marco, Gerace Dario, O’Faolain Liam, Andreani Lucio Claudio   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Low-light-level nonlinear optics with slow light

, 2003
Electromagnetically induced transparency in an optically thick, cold medium creates a unique system where pulse-propagation velocities may be orders of magnitude less than $c$ and optical nonlinearities become exceedingly large.
A. Furusawa, A. Kuzmich, A.S. Zibrov, C.G. Townsend, C.H. van der Wal, Carlo Ottaviani, Danielle A. Braje, David Petrosyan, G. Y. Yin, H. Schmidt, J.P. Marangos, L.-M. Duan, L.V. Hau, M. Prevedelli, M.D. Lukin, M.D. Lukin, Mattias T. Johnsson, Michael Kash, Min Yan, Phillips, S. E. Harris, S.E. Harris, S.E. Harris, S.E. Harris, Vlatko Balić, Wolfgang Ketterle, Ying-Cheng Chen   +26 more
core   +1 more source

Distributed Temperature Sensing Using Stimulated-Brillouin-Scattering-Based Slow Light

IEEE Photonics Journal, 2013
Distributed temperature sensing has been achieved by spatially resolved measurement of the probe time delay resulted from stimulated-Brillouin-scattering slow light. The temperature of a particular fiber section can be monitored by setting an appropriate
Liang Wang, Bin Zhou, Chester Shu, Sailing He   +3 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Competition between the Modulation Instability and Stimulated Brillouin Scattering in a Broadband Slow Light Device

, 2010
We observe competition between the modulation instability (MI) and stimulated Brillouin scattering (SBS) in a 9.2-GHz broadband SBS slow light device, in which a standard 20-km-long single-mode LEAF fibre is used as the SBS medium.
Agrawal G, Alexander L Gaeta, Boyd R, Daniel J Gauthier, E Cabrera-Granado, Oscar G Calderon, Sonia Melle, Yoshitomo Okawachi, Yunhui Zhu   +8 more
core   +1 more source

Tunable Slow Light in Valley-Locked Topological Photonic Crystal Waveguide

Photonics
This study introduces a topological photonic slow-light waveguide based on a honeycomb unit cell, which allows for the convenient tuning of the group index and bandwidth through the valley-locked effect.
Chenyang Peng, Gang Li, Junhao Yang, Chunlin Ma, Xinyuan Qi   +4 more
doaj   +1 more source

Electrical Manipulation of Electromagnetically Induced Transparency for Slow Light Purpose Based on Metal-Graphene Hybrid Metamaterial

Applied Sciences, 2018
A terahertz metamaterial is presented and numerically investigated to achieve tunable electromagnetically induced transparency (EIT) for slow light. The unit cell consists of cut-wire pairs and U-shaped ring resonators with graphene strips placed between
Chenxi Liu, Song Zha, Peiguo Liu, Cheng Yang, Qihui Zhou   +4 more
doaj   +1 more source