Results 71 to 80 of about 2,387,223 (285)

Slow-light enhanced absorption for bio-chemical sensing applications: potential of low-contrast lossy materials [PDF]

open access: yesJournal of the European Optical Society-Rapid Publications, 2008
Slow-light enhanced absorption in liquid-infiltrated photonic crystals has recently been proposed as a route to compensate for the reduced optical path in typical lab-on-a-chip systems for bio-chemical sensing applications.
Pedersen Jesper   +2 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

Slow, Stored and Stationary Light [PDF]

open access: yes, 2016
Slow light has received growing interest since 1999 when the propagation velocity of light was reduced in an experiment to 17 m/s, i.e. almost 20 million times slower than in vacuum. Two years later light pulses were stopped, or more specifically stored in an atomic medium and subsequently released after some time. This provided the basis for important
Fleischhauer, Michael   +1 more
openaire   +2 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

open access: yesMolecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken   +7 more
wiley   +1 more source

Slow light with a swept-frequency source

open access: yes, 2010
We introduce a new concept for stimulated-Brillouin-scattering-based slow light in optical fibers that is applicable for broadly-tunable frequency-swept sources.
Boyd   +21 more
core   +1 more source

Low-distortion slow light using two absorption resonances [PDF]

open access: yes, 2006
We consider group delay and broadening using two strongly absorbing and widely spaced resonances. We derive relations which show that very large pulse bandwidths coupled with large group delays and small broadening can be achieved.
Camacho, Ryan M.   +2 more
core   +3 more sources

Room-Temperature Slow Light in a Coupled Cavity Magnon-Photon System

open access: yesIEEE Access, 2019
Realizing room-temperature slow light is of fundamental importance in physics and may promote the practical applications of slow light in information storage and optical communication.
Zeng-Xing Liu, Hao Xiong, Ying Wu
doaj   +1 more source

Actively tunable and switchable electromagnetically induced transparency in hybrid metal-graphene metamaterials

open access: yesMaterials Research Express, 2021
Active control of the electromagnetically induced transparency (EIT) is highly desirable for advanced terahertz (THz) device applications. Currently, the EIT peak positions in the graphene-based metamaterials have been actively controlled by tailoring ...
Xiaoming Xu   +4 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

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