Results 41 to 50 of about 738,405 (343)
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
An Investigation on Hydrogen Embrittlement of the Cr-Si Spring Steel Using Slow Strain Rate Test and Weibull Model [PDF]
International Journal of Advanced Design and Manufacturing Technology, 2015 In this paper, the hydrogen embrittlement of the high strength Cr-Si spring steel with after Zn-12%Ni electroplating, have been evaluated. Slow strain rate test with 3.34 × 10-6 sec-1 strain rate was performed, and the hydrogen embrittlement index of the
Hamid Nazemi, Maryam Ehteshamzadeh
doaj
Reducing ppGpp level rescues an extreme growth defect caused by mutant EF-Tu.
PLoS ONE, 2014 Transcription and translation of mRNA's are coordinated processes in bacteria. We have previously shown that a mutant form of EF-Tu (Gln125Arg) in Salmonella Typhimurium with a reduced affinity for aa-tRNA, causes ribosome pausing, resulting in an ...
Jessica M Bergman +2 more
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Effect of Microstructural Constituents on Hydrogen Embrittlement Resistance of API X60, X70, and X80 Pipeline Steels [PDF]
Archives of Metallurgy and MaterialsThis study describes how microstructural constituents affected the hydrogen embrittlement resistance of high-strength pipeline steels. The American Petroleum Institute (API) X60, X70, and X80 pipeline steels demonstrated complicated microstructure ...
Seung-Hyeok Shin +3 more
doaj +3 more sources
Flow transitions in two-dimensional foams
, 2006 For sufficiently slow rates of strain, flowing foam can exhibit inhomogeneous flows. The nature of these flows is an area of active study in both two-dimensional model foams and three dimensional foam. Recent work in three-dimensional foam has identified
C. Macosko +5 more
core +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source