Results 61 to 70 of about 738,405 (343)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

The delayed fracture evaluation of high tensile steel sheet, and the influence of experimental methods

Nihon Kikai Gakkai ronbunshu, 2019
In order to apply the high strength steel sheet with tensile strength is above 1200MPa, it is necessary to assess the delayed fracture susceptibility caused by hydrogen entering from the environment where steel components are exposed, and also necessary ...
Aya TSUJI, Tomohiro SUZUKI, Gaku KITAHARA, Takashi ASADA   +3 more
doaj   +1 more source

Effects of an Unusual Poison Identify a Lifespan Role for Topoisomerase 2 in Saccharomyces Cerevisiae [PDF]

, 2017
A progressive loss of genome maintenance has been implicated as both a cause and consequence of aging. Here we present evidence supporting the hypothesis that an age-associated decay in genome maintenance promotes aging in Saccharomyces cerevisiae (yeast)
Baxter, Bonnie, Gilbertson, Matthew, Goldfarb, David S., Madrey, Joe, Millen, Jonathan, Nitiss, John L., Piazza, Gary A., Polevoda, Bogdan, Rapaport, Matan, Rasmussen, Lynn, Tombline, Gregory, Van Meter, Michael, Wennerberg, Kirster, White, E. Lucile   +13 more
core   +2 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

Study on stress corrosion behavior of 316L austenitic stainless steel in hot NaOH solution

Journal of Materials Research and Technology
In this study, slow strain rate test (SSRT), X-ray photoelectron spectroscopy (XPS), electrochemical impedance spectroscopy (EIS), and scanning electron microscopy (SEM) were used to investigate the stress corrosion behavior of 316L austenitic stainless ...
Yun Liu, Hailong Dai, Sheng Chen, Meng He, Shouwen Shi, Zhe Zhang, Xu Chen   +6 more
doaj   +1 more source

Investigation of Stress Corrosion Cracking Behaviour of Mg-Al-Zn Alloys in Different pH Environments by SSRT Method

Open Chemistry, 2019
In this study, stress corrosion behaviors of AZ31, AZ61 and AZ91 Mg alloys which contain different amounts of Al were investigated under acidic, basic and neutral environments having chloride ions using Slow Strain Rate Test (SSRT) method.
Catar Recep, Altun Hikmet
doaj   +1 more source

Static and dynamic aspects of coupling between creep behavior and oxidation on MC2 single crystal superalloy at 1150 °C [PDF]

, 2005
Creep tests were performed on thin wall specimens made of MC2 single crystal superalloy at 1150 °C and under controlled atmosphere. The results highlight the deleterious oxidation effect on creep properties.
Andrieu, Eric, Crabos, Fabrice, Dryepondt, Sébastien, Monceau, Daniel   +3 more
core   +2 more sources

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source

Translation elongation can control translation initiation on eukaryotic mRNAs [PDF]

, 2013
Synonymous codons encode the same amino acid, but differ in other biophysical properties. The evolutionary selection of codons whose properties are optimal for a cell generates the phenomenon of codon bias.
Aitken, Anand, Brachmann, Browne, Carlini, Chan, Charneski, Chu, Chu, Chu, Ciandrini, Dana, Firczuk, Fluitt, Gibson, Gould, Grant, Haar, Haar, Hense, Hershberg, Hu, Ikemura, Ingolia, Ingolia, Jeon, Kemp, Kotula, Kudla, Liti, Liu, Lombardi, McCarthy, Merritt, Mirzaei, Moriya, Mossadegh, Nagata, Neafsey, Outchkourov, Patel, Plant, Powell, Qian, Sala-Newby, Salas-Marco, Shalgi, Sikorski, Sinclair, Slimko, Stadler, Stark, Wolin, Yadava, Zhou, Zouridis   +55 more
core   +2 more sources