Results 171 to 180 of about 272,409 (339)

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems

Advanced Science, EarlyView.
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Hind Abdo, Leonardo Barzaghi, Yuan Shen, Edoardo Bellini, Emanuele Martini, Serena Magni, Sara Barozzi, Fabrizio Orsenigo, Dario Parazzoli, Galina V. Beznoussenko, Jasmin Di Franco, Fabian Krautgasser, Jasmin Kaivola, Mario Cinquanta, Alessandro Lazzarin, Sara Sigismund, Johanna Ivaska, Roberto Cerbino, Giorgio Scita   +18 more
wiley   +1 more source

Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression

, 2007
John Frater, Helen Brown, Annette Oxenius, Huldrych F. Günthard, Hans H. Hirsch, Nicola Robinson, Alasdair Leslie, Rebecca Payne, Hayley Crawford, Andrew J. Prendergast, Christian Brander, Photini Kiepiela, Bruce D. Walker, Philip Goulder, Angela R. McLean, Rodney E. Phillips   +15 more
openalex   +1 more source

Extracellular Vesicle‐Delivered tRF‐His‐GTG‐1 Reprograms Neutrophil Lipophagy and Triggers Inflammation in COVID‐19

Advanced Science, EarlyView.
This study identifies platelet‐derived extracellular vesicles as key immunometabolic regulators in COVID‐19. The delivery of tRF‐His‐GTG‐1 to neutrophils activates TLR8mTOR signaling, disrupts lipophagy, and amplifies NET‐mediated inflammation. Importantly, targeting this axis restores neutrophil homeostasis, offering a potential therapeutic strategy ...
Tsai‐Ling Liao, Po‐Yu Liu, Yi‐Ming Chen, Kuo‐Tung Tang, Hung‐Jen Liu, Der‐Yuan Chen   +5 more
wiley   +1 more source

Incorporation of arabinose-CTP and arabinose-UTP inhibits viral polymerases by inducing long pauses. [PDF]

J Biol Chem
Xiao Z, Das A, Jain A, Anderson TK, Cameron CE, Arnold JJ, Dulin D, Kirchdoerfer RN.   +7 more
europepmc   +1 more source

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source

The potential impact of public health care denial on the transmission dynamics of COVID-19 in South Africa. [PDF]

Sci Prog
Juga M, Nyabadza F.
europepmc   +1 more source

DNA Polymerase Activities in Virions of Visna Virus, a Causative Agent of a “Slow” Neurological Disease

, 1971
Jeffrey Schlom, Donald H. Harter, Arsène Burny, S. Spiegelman   +3 more
openalex   +2 more sources

Exclusive Breastfeeding Drives AMPK‐Dependent Thermogenic Memory in BAT and Promotes Long‐Term Metabolic Benefits in Offspring

Advanced Science, EarlyView.
Exclusive breastfeeding establishes a thermogenic memory in brown adipose tissue by activating the HIF1AN/AMPK/α‐ketoglutarate axis via milk‐derived extracellular vesicles enriched in miR‐125a‐5p. This programming preserves metabolic health, while αKG supplementation restores BAT function under mixed feeding, offering strategies to mitigate the ...
Ningxi Wu, Anwen Yin, Xiang Yu, Mingxin Wang, Jiahui Zhang, Kerong Liu, Yutong Hou, Minkai Cao, Yiting Zhang, Xiaoxiao Zhang, Yao Gao, Xirong Guo, Le Zhang, Yun Li   +13 more
wiley   +1 more source

West Nile Virus-Associated Hemophagocytic Lymphohistiocytosis, Switzerland. [PDF]

Emerg Infect Dis
Lascano C, Groenendijk L, Bruno B, Meduri E, Malclès A, Laubscher F, Pérez-Rodriguez FJ, Schibler M, Marti C, Nguyen A.   +9 more
europepmc   +1 more source

Slow viruses and chronic disease: the contribution of epidemiology.

, 1980
Neal Nathanson
openalex   +1 more source