Results 91 to 100 of about 767,866 (294)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

A new approach to the design of time varying control systems with application to the space shuttle booster [PDF]

open access: yes
A general approach toward the analysis and design of closed loop control for slowly time-varying linear systems was investigated. The approach is by the method of generalized multiple scales, in which slow and fast dynamics are systematically separated ...
Ramnath, R. V.
core   +1 more source

Dynamical Synapses Enhance Neural Information Processing: Gracefulness, Accuracy and Mobility

open access: yes, 2012
Experimental data have revealed that neuronal connection efficacy exhibits two forms of short-term plasticity, namely, short-term depression (STD) and short-term facilitation (STF).
C. C. Alan Fung   +7 more
core   +2 more sources

Overview of molecular signatures of senescence and associated resources: pros and cons

open access: yesFEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

open access: yesFEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz   +9 more
wiley   +1 more source

Adaptive Network Selection for Latency-Aware V2X Systems Under Varying Network and Vehicle Densities

open access: yesIEEE Access
This paper presents ANS-V2X, an Adaptive Network Selection framework tailored for latency-aware V2X systems operating under varying vehicle densities and heterogeneous network conditions.
Muhammad Z. Haq   +5 more
doaj   +1 more source

Exact time dependence of causal correlations and nonequilibrium density matrices in holographic systems

open access: yes, 2017
We present the first exact calculations of the time dependence of causal correlations in driven nonequilibrium states in (2+1)-dimensional systems using holography.
Joshi, Lata Kh   +3 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Information-Theoretic Analysis of Underwater Acoustic OFDM Systems in Highly Dispersive Channels

open access: yesJournal of Electrical and Computer Engineering, 2012
This paper investigates the signal-to-interference ratio and the achievable rates of underwater acoustic (UA) OFDM systems over channels where time and frequency dispersion are high enough that (i) neither the transmitter nor the receiver can have a ...
Francois-Xavier Socheleau   +3 more
doaj   +1 more source

Computer Simulation of Current Forces on Motion of Floating Production Storage and Offloading in Irregular Waves [PDF]

open access: yes, 2010
This paper presents the effect of current forces on the motion of forces on Floating Production Storage and Offloading (FPSO) in irregular waves. The objective of this research is to compute the motion of FPSO in irregular waves by time domain simulation
Abdul Malik, Adi Maimun   +3 more
core  

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