Results 71 to 80 of about 767,866 (294)

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source

Fundamental limits to position determination by concentration gradients.

PLoS Computational Biology, 2007
Position determination in biological systems is often achieved through protein concentration gradients. Measuring the local concentration of such a protein with a spatially varying distribution allows the measurement of position within the system.
Filipe Tostevin, Pieter Rein ten Wolde, Martin Howard   +2 more
doaj   +1 more source

Design of a Discrete-time Sliding Mode Controller for Nonlinear Affine Systems based on Disturbance Estimation [PDF]

Journal of Electrical and Computer Engineering Innovations, 2017
Background and Objectives: Nowadays, because of accuracy, speed, cost, and flexibility of digital control laws, control systems are implemented by computers, microprocessors or DSP chips.
N. Azam Baleghi, M.H. Shafiei
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Monitoring Fracture Hydromechanical Evolution in the Lab and Field Using Unsupervised Metric Learning

Journal of Geophysical Research: Machine Learning and Computation
Fractures evolve in time through thermal‐hydraulic‐mechanical‐chemical (THMC) processes that alter their long‐range hydraulic transport properties and modify subsurface behavior and activities.
David D. Nolte, Laura J. Pyrak‐Nolte, Chet Hopp   +2 more
doaj   +1 more source

Universal state conversion in discrete and slowly varying non-Hermitian cyclic systems: An analytic proof and exactly solvable examples

Physical Review Research, 2023
In this paper, we formally prove how, by cyclically varying the parameters of a generalized two-level discrete and non-Hermitian Hamiltonian, the respective state vector converts to the instantaneous eigenstate of the system in the adiabatic limit ...
Nicholas S. Nye
doaj   +1 more source

Slow dynamics and thermodynamics of open quantum systems

, 2017
We develop a perturbation theory of quantum (and classical) master equations with slowly varying parameters, applicable to systems which are externally controlled on a time scale much longer than their characteristic relaxation time.
Cavina, Vasco, Giovannetti, Vittorio, Mari, Andrea   +2 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Brownian Dynamics Simulation of Polydisperse Hard Spheres

, 2012
Standard algorithms for the numerical integration of the Langevin equation require that interactions are slowly varying during to the integration timestep.
A. Scala, A. Scala, A. Scala, A. Yethiraj, B. Cichocki, B. Cichocki, B.J. Ackerson, G. De Fabritiis, G. Foffi, G. Lamm, H. Trotter, H.A. Kramers, M. Krüger, M. Krüger, M. Marechal, M. Terada, M.H. Ernst, M.V. Smoluchowski, O. Henrich, P. Strating, P.N. Pusey, S. Hanna, T.M.A.O.M. Barenbrug, T.P.C. van Noije, W. Schaertl   +24 more
core   +1 more source