Results 81 to 90 of about 767,866 (294)
Molecular Oncology, EarlyView.To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Stabilization of slowly time-varying discrete systems with state delays
Journal of Difference Equations and Applications, 2013 This paper studies the stabilization of the infinite-dimensional linear discrete time-varying systems with state delays and slowly varying coefficients , , where A(k) are bounded linear operators acting on a Banach space X, B(k) are X-valued bounded linear operators defined on a Banach space U and A 1(k) are bounded linear operators acting on a Banach ...
openaire +3 more sources
Molecular Oncology, EarlyView.Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley +5 more
wiley +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Slow and fast systems with Hamiltonian reduced problems
Electronic Journal of Differential Equations, 2010 Slow and fast systems are characterized by having some of the derivatives multiplied by a small parameter $epsilon$. We study systems of reduced problems which are Hamiltonian equations, with or without a slowly varying parameter.
Maamar Benbachir +2 more
doaj
A Note on Exponential Stability of Partially Slowly Time-Varying Nonlinear Systems
IFAC Proceedings Volumes, 1998 Abstract Consider a system x ˙ = ( x , t , t β ) with a time-varying vectorfield which contains a regular and a slow time scale (β3 large). Assume there exist an α(τ) and a K(τ) such that ‖ x τ ( t , t 0 , x 0 ) ‖ ≤ k ( τ ) ‖ x 0 ‖ e α ( τ ) ( t − t 0 ) where x ...
Joan Peuteman, Dirk Aeyels
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Time-scale separation based design of biomolecular feedback controllers (extended version) [PDF]
, 2019 Time-scale separation is a powerful property that can be used to simplify control systems design. In this work, we consider the problem of designing biomolecular feedback controllers that provide tracking of slowly varying references and rejection of ...
Del Vecchio, Domitilla +1 more
core
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
A Reference Trajectory Based Discrete Time Sliding Mode Control Strategy
International Journal of Applied Mathematics and Computer Science, 2019 This study presents a new, reference trajectory based sliding mode control strategy for disturbed discrete time dynamical systems. The desired trajectory, which is generated externally according to an existing switching type reaching law, determines the ...
Bartoszewicz Andrzej, Adamiak Katarzyna
doaj +1 more source
Inherent robustness of discrete-time adaptive control systems [PDF]
Global stability robustness with respect to unmodeled dynamics, arbitrary bounded internal noise, as well as external disturbance is shown to exist for a class of discrete-time adaptive control systems when the regressor vectors of these systems are ...
Ma, C. C. H.
core +1 more source