Results 101 to 110 of about 6,925,642 (276)

Limit distributions of vertex degrees in a conditional configuration graph

open access: yesTransactions of the Karelian Research Centre of the Russian Academy of Sciences, 2018
The configuration graph where vertex degrees are independent identically distributed random variables is often used for  modeling of complex networks such as the Internet. We consider a random graph consisting of   N vertices.
Irina Chepliukova, Yuri Pavlov
doaj   +1 more source

Functional limit theorems for the Bouchaud trap model with slowly varying traps

open access: yesStochastic Processes and their Applications, 2015
We consider the Bouchaud trap model on the integers in the case that the trap distribution has a slowly varying tail at infinity. Our main result is a functional limit theorem for the model under the annealed law, analogous to the functional limit theorems previously established in the literature in the case of integrable or regularly varying trap ...
David Croydon, Stephen Muirhead
openaire   +2 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Flesh-Colored Papules on the Glans Penis

open access: yesDermatopathology
A 23-year-old man reported a 3-year history of slowly growing, slightly itchy, flesh-colored papules on the distal glans penis. He denied any history of trauma or previous treatment. Additionally, he experienced no difficulties with urination, discharge,
Phatcharawat Chirasuthat   +2 more
doaj   +1 more source

A holographic cut-off inspired in the apparent horizon

open access: yesEuropean Physical Journal C: Particles and Fields, 2018
In this work we consider a general function for the $$c^{2}$$ c2 term that appears in the conventional expression for the holographic dark energy in a FLRW curved spacetime. The cut-off prospective is inspired in the apparent horizon length. By exploring
Miguel Cruz, Samuel Lepe
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Multiuser Delay-Tracking CDMA Receiver

open access: yesEURASIP Journal on Advances in Signal Processing, 2002
We propose to integrate delay tracking into a successive interference cancellation (SIC) code division multiple access (CDMA) multiuser detector. Delay-robust SIC was initially proposed for CDMA multiuser detection when there exist time delay estimation
Zha Wei, Blostein Steven D
doaj   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

open access: yesMolecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder   +10 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

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