Results 111 to 120 of about 6,925,642 (276)
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
MORE ON TRANSLATIONALLY SLOWLY VARYING SEQUENCES [PDF]
, 2019 We define and study an equivalence relation in the class Tr(SVs) of translationally slowly varying positive real sequences and its relations with selection principles and game theory.
Đurčić, Dragan, Kocinac, Ljubisa
core
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source
A Measure of Variability in Comovement for Economic Variables : a Time-Varying Coherence Function Approach [PDF]
In this paper, we test the instability of comovement, in time and frequency domain, for the GDP growth rate of the US and the UK. We use the frequency approach, which is based on evolutionary spectral analysis (Priestley, 1965-1996).
Mohamed Boutahar, Essahbi Essaadi
core +4 more sources
Физика волновых процессов и радиотехнические системы, 2018 The quality of wave-front reversal has been studied at degenerate four-wave interaction in two-dimensional multimode waveguide with resonant nonlinearity using the Point-Spread Function (PSF) method. It has been shown that over time the PSF-module width,
E.V. Vorobyeva +2 more
doaj
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
SPECTRAL ASYMPTOTICS FOR MAGNETIC SCHRÖDINGER OPERATOR WITH SLOWLY VARYING POTENTIAL [PDF]
Consider the Schrödinger operator with constant magnetic field and smooth potential V : H(ϵ) = H + V(ϵx, ϵy), H = D＾2_x + (D_y + μx)², (x, y) ∈ Ω_d, with Dirichlet boundary conditions. Here Ω_d = Π^d_] − a_j, a_j[×ℝ^d_y.
Dimassi, Mouez +2 more
core +2 more sources
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source