Results 101 to 110 of about 631,519 (293)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Theory of Run-Length Domain Modal Decomposition for Assessing Dynamic Errors in Electricity Meter

IEEE Access
In scenarios involving photovoltaic power generation and electrical dynamic loads, complex electricity metering signals often exhibit strong randomness and rapid fluctuations.
Ruiming Yuan, Wenwen Li, Guoxing Wang, Di Wu, Shiyu Xie, Xuewei Wang   +5 more
doaj   +1 more source

Functional limit theorems for the Bouchaud trap model with slowly varying traps

Stochastic Processes and their Applications, 2015
We consider the Bouchaud trap model on the integers in the case that the trap distribution has a slowly varying tail at infinity. Our main result is a functional limit theorem for the model under the annealed law, analogous to the functional limit theorems previously established in the literature in the case of integrable or regularly varying trap ...
David Croydon, Stephen Muirhead
openaire   +2 more sources

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

An Adaptive Fuzzy Level Set Model With Local Spatial Information for Medical Image Segmentation and Bias Correction

IEEE Access, 2019
Medical image segmentation is still a challenging task due to noise and intensity inhomogeneity. An adaptive fuzzy level set model (AFLSM) with local spatial information is presented in this paper for accurately segmenting medical images and correcting ...
Zhe Zhang, Jianhua Song
doaj   +1 more source

Dissipative quantum mechanics beyond Bloch-Redfield: A consistent weak-coupling expansion of the ohmic spin boson model at arbitrary bias

, 2018
We study the time dynamics of the ohmic spin boson model at arbitrary bias $\epsilon$ and small coupling $\alpha$ to the bosonic bath. Using perturbation theory and the real-time renormalization group (RG) method we present a consistent zero-temperature ...
Lindner, Carsten J., Schoeller, Herbert
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Dipole superfluid hydrodynamics. Part II.

Journal of High Energy Physics
We present a dissipative hydrodynamic theory of “s-wave dipole superfluids” that arise in phases of translation-invariant and dipole-symmetric models in which the U(1) symmetry is spontaneously broken. The hydrodynamic description is subtle on account of
Akash Jain, Kristan Jensen, Ruochuan Liu, Eric Mefford   +3 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source