Results 91 to 100 of about 59,977 (353)

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

open access: yesAdvanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Experimental Study on Two-phase Flow and Vibration Characteristics of Marine Riser

open access: yesShiyou jixie, 2016
In order to identify flow patterns that may occur in the marine riser system and study the dynamic response of the riser under different flow patterns,two-phase flow pressure fluctuations in the riser and resulting riser vibration displacement were ...
Liu Chang   +4 more
doaj  

Intracellular Reactive Oxygen Species Generation Induced by High‐Frequency Ultrasound in Thickness Vibration Mode

open access: yesAdvanced Science, EarlyView.
Cell‐sized high‐frequency ultrasound using a lithium niobate transducer, previously ignored in reactive oxygen species (ROS) production, generated intracellular ROS at frequencies higher than conventionally used. The intracellular generation of ROS by cell‐sized high‐frequency ultrasound revealed in this study is expected to be applied to innovative ...
Kotaro Fujishiro   +4 more
wiley   +1 more source

Numerical Modelling of Gas-Liquid Slug Flow Regime with a Conservative Two-Fluid Model Using the Shock Capturing Method [PDF]

open access: yesIranian Journal of Chemistry & Chemical Engineering
An approach for simulating the initiation of slugs in horizontal pipes is proposed in this research. An analogy is established between the algorithms for solving single-phase problems with discontinuity (Riemann problems) and two-phase slug flow (having ...
Mohammad Hassan Yahyanezhad   +2 more
doaj   +1 more source

Slug Regime Transitions in a Two-Phase Flow in Horizontal Round Pipe. CFD Simulations

open access: yesApplied Sciences, 2020
The main objective of the study is to propose a technical solution integrated into the pipeline for the transition of the flow regime from slug to bubbly two-phase flow.
Vitaly Sergeev   +4 more
doaj   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

open access: yesAdvanced Science, EarlyView.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu   +7 more
wiley   +1 more source

Prediction model of fluctuation frequencies induced by continuity waves in slug flow

open access: yesYou-qi chuyun
[Objective] Slug flow is one of the main gas-liquid two-phase flow regimes. Its fluctuation characteristics not only impact the safe operation of multi-phase pumps and the measurement accuracy of multi-phase flowmeters but also arouse flow-induced ...
ZHOU Mingwei   +4 more
doaj   +1 more source

A PLIC-VOF-Based Simulation of Water-Organic Slug Flow Characteristics in a T-Shaped Microchannel

open access: yesAdvances in Mechanical Engineering, 2013
A water-organic slug flow in a T-shaped microchannel was numerically studied due to its importance in the microreactor system. Various factors affecting the flow mode were studied, for example, channel width, fluid viscosity, interfacial tension, and ...
Xian Wang, Hiroyuki Hirano, Gongnan Xie
doaj   +1 more source

Co-current horizontal flow of a Newtonian and a non-Newtonian fluid in a microchannel [PDF]

open access: yes, 2014
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014)   +4 more
core  

Pellet Printing for Soft Robotic Devices

open access: yesAdvanced Science, EarlyView.
Fused Granulate Fabrication (FGF) is established here as a reliable method for fabricating soft, airtight robotic devices. Through coordinated optimization of hardware, material selection, and process parameters, this approach enables high‐speed printing of thermoplastic elastomers with silicone‐like softness and modulus.
Yijia Wu   +6 more
wiley   +1 more source

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