Results 131 to 140 of about 10,594 (216)

Slug-flow microchannel enables efficient and controllable preparation of sensitive protein nanoparticles. [PDF]

Commun Chem
Gao Z, Zhang Y, Tan A, Chen P, Liu S, Qiu M, Wang Z, Ma Y, Qian G, Schuurmans JHA, Shang M, Jin X, Noёl T, Su Y.   +13 more
europepmc   +1 more source

Effect of Sand Fines Concentration on the Erosion-Corrosion Mechanism of Carbon Steel 90° Elbow Pipe in Slug Flow. [PDF]

Materials (Basel), 2020
Khan R, H Ya H, Pao W, Majid MAA, Ahmed T, Ahmad A, Alam MA, Azeem M, Iftikhar H.   +8 more
europepmc   +1 more source

Mechanistic Analysis of Drug Linker Clearance During Ultrafiltration/Diafiltration of an Antibody–Drug Conjugate

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Ultrafiltration/diafiltration (UF/DF) is a key unit operation in the manufacture of antibody‐drug conjugates (ADCs), commonly utilized for post‐conjugation purification to remove residual Drug Linker (DL) compounds and affect buffer exchange.
Vasudev Tangry, Fara Lyu, Amy Le, Laurie Mlinar, Manish S. Kelkar, Andrew L. Zydney   +5 more
wiley   +1 more source

Leveraging an intelligent slug flow platform for self-optimization of reaction systems with categorical variables. [PDF]

Chem Sci
Wagner FL, Neun G, Tampone T, Lei Z, Buono FG, Hone CA, Kappe CO.   +6 more
europepmc   +1 more source

Unmasking Glycoforms: Lectin‐Based Profiling and Functional Implications of Targeted Glycosylation Knockouts in Chinese Hamster Ovary Cells

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Monoclonal antibody (mAb) glycosylation is a critical quality attribute that is difficult to rationally engineer and rapidly assess during cell line development. Here, we investigate whether cell‐surface glycosylation can serve as a surrogate readout of mAb product glycosylation following targeted glycogene engineering in CHO cells.
Cristina Abascal Ruiz, Sheryl Li Yan Lim, Jacobus Brink, Sara Carillo, Eoin Casey, Jonathan Bones, Ioscani Jiménez del Val   +6 more
wiley   +1 more source

Experimental and Numerical Study of Slug-Flow Velocity Inside Microchannels Through In Situ Optical Monitoring. [PDF]

Micromachines (Basel)
Moscato S, Cutuli E, Camarda M, Bucolo M.   +3 more
europepmc   +1 more source

Scale‐Down Platforms for Process‐Oriented Enzyme Screening Using Microfluidics

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Enzyme screening platforms are typically evaluated based on their throughput and analytical performance rather than their ability to mimic the conditions encountered at large scale. In bioreactors, enzymes experience gradients in substrate concentration, oxygen availability, pH, temperature, and interfacial exposure, caused by imperfect mixing
Maria I. Rodriguez‐Torres, Elif Erdem, Junhyeong Wang, Ulrich Krühne, Michael Daniele, John M. Woodley   +5 more
wiley   +1 more source

Tackling cancer stemness with nanotechnology in the era of precision medicine

BMEMat, EarlyView.
Precise customization of nanoparticles (NPs) enables active targeting of cancer stem cells (CSCs), thereby improving drug delivery and therapeutic efficacy. NP‐based probing enhances CSC detection through imaging and liquid biopsy, whereas diverse therapeutic payloads improve therapeutic outcomes.
Shaolei Guo, Shun Yao, Lihui Meng, Chunyuan Chen, Yuechu Lucinda Lu, Rong Lu, Kashif Rafiq Zahid, Umar Raza, Qingzhi Wu, Wenli Chen   +9 more
wiley   +1 more source

Navigating the Double Edge of Product‐Service Systems: User Behavior, Adoption, and Rebound Effects

Business Strategy and the Environment, EarlyView.
ABSTRACT Product‐service systems (PSS) have been considered a promising approach to operationalizing the circular economy. Although many studies have outlined the potential sustainability gains of PSS solutions, it is still unclear what factors drive PSS adoption and how behavioral changes result in rebound effects, undermining their potential ...
Marina Fernandes Aguiar, Daniel Guzzo, Janaina Mascarenhas, Daniela C. A. Pigosso   +3 more
wiley   +1 more source

Operations Research‐Based Formalisation and Design of Sustainable Reverse Logistics for E‐Waste Supply Chains

Business Strategy and the Environment, EarlyView.
ABSTRACT This study demonstrates how a profitable, lean, and environmentally responsible e‐waste reverse logistics system can be designed using integrated Operations Research (OR) techniques. Addressing the growing urgency of responsible consumption (UN SDG 12) and the projected rise of the e‐waste sector to USD 137.60 billion by 2029, the research ...
Sheeba Pathak, Hajar Fatorachian
wiley   +1 more source