Results 41 to 50 of about 59,977 (353)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

open access: yesFEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava   +3 more
wiley   +1 more source

Preliminary Results of Numerical Simulation of Slug Flow in a Regular T-Junction

open access: yesMATEC Web of Conferences, 2018
Excessive liquid carryover in T-junction due to splitting nature of two-phase flow causes serious issues in piping system. A three-dimensional numerical model is employed to investigate two-phase flow split behavior of slug flow in a circular-section ...
Tran Minh   +3 more
doaj   +1 more source

R134a flow patterns in small diameter tubes [PDF]

open access: yes, 2004
R134a vapour-liquid two-phase flow patterns were studied in vertical small diameter tubes. The observed flow patterns include bubbly, dispersed bubble, slug, churn, annular and mist flow.
Chen, L, Karayiannis, TG, Tian, YS
core  

Numerical simulation of bubble generation in a T-junction [PDF]

open access: yes, 2012
We present a numerical study of the formation of mini-bubbles in a 2D T-junction by means of the fluid dynamics numerical code JADIM. Numerical simulations were carried out for different flow conditions, giving rise to results on the behavior of bubble ...
Arias, Santiago   +2 more
core   +4 more sources

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

open access: yesFEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda   +12 more
wiley   +1 more source

Hydraulic model of steady state multiphase flow in wellbore annuli

open access: yesPetroleum Exploration and Development, 2014
Based on the classification and flow behaviors of two phase flow in wellbore annuli, the hydraulic models for slug flow and annular flow in annuli for vertical or inclined wells were established, and the flow regime transition criteria were also obtained.
Bangtang YIN   +3 more
doaj   +1 more source

The effect of tube diameter on vertical two-phase flow regimes in small tubes [PDF]

open access: yes, 2006
Flow boiling flow patterns in four circular tubes with internal diameters of 1.10, 2.01, 2.88 and 4.26 mm were investigated in the present project. The experiments were conducted in vertical upward two-phase flow using R134a as the working fluid.
Chen, L, Karayiannis, TG, Tian, YS
core  

Sertraline Treatment Can Mimic Niemann‐Pick Type C Biomarker Profile: A Diagnostic Pitfall

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Oxysterols (cholestane‐3β,5α,6β‐triol and 7‐ketocholesterol) and N‐palmitoyl‐O‐phosphocholineserine (PPCS) are sensitive biomarkers for Niemann‐Pick disease type C (NPC) screening. However, false‐positive results occur, with a biomarker profile suggestive of NPC despite the absence of pathogenic variants in genes involved in NPC or ...
Maria Makrygianni   +19 more
wiley   +1 more source

Vertical upward flow patterns in small diameter tubes [PDF]

open access: yes, 2005
Two-phase flow patterns were studied in vertical small diameter tubes using R134a as the working fluid. The observed flow patterns include bubbly, dispersed bubble, confined bubble, slug, churn, annular and mist flow.
Chen, L, Karayiannis, TG, Tian, YS
core  

What Do Large Language Models Know About Materials?

open access: yesAdvanced Engineering Materials, EarlyView.
If large language models (LLMs) are to be used inside the material discovery and engineering process, they must be benchmarked for the accurateness of intrinsic material knowledge. The current work introduces 1) a reasoning process through the processing–structure–property–performance chain and 2) a tool for benchmarking knowledge of LLMs concerning ...
Adrian Ehrenhofer   +2 more
wiley   +1 more source

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