Results 101 to 110 of about 5,855,904 (273)

Ribonucleotides Amplify Mitochondrial DNA‐Driven cGAS–STING Activation via FdUMP‐ribonucleotide Hybrid Particles to Potentiate Chemoimmunotherapy

Advanced Science, EarlyView.
This work develops a metabolic sharing strategy that employs cytidine monophosphate (CMP) to competitively reprogram floxuridine (FUDR) pyrimidine metabolism in colorectal tumor cells. Elevated intracellular FdUMP induces nucleotide imbalance, drives mitochondrial DNA release and cGAS‐STING innate immune cascade activation, and potentiates robust ...
Chao Wang, Chenxuan Zhao, Yesong Yao, Zhiwen Zou, Anxin Shi, Zhuo Feng, Mingkang Yang, Yue Yu, Yang Liu, Xuehui Rui, Jinhui Wu   +10 more
wiley   +1 more source

Radiographic assessment of the cardiac silhouette in clinically normal large- and small-breed dogs

American Journal of Veterinary Research, 2017
Abstract OBJECTIVE To determine manubrium heart scores (MHSs) from measurements of cardiac short-axis length (cSAL) and long-axis length (cLAL) relative to the corresponding manubrium length (ML) on thoracic radiographic views of dogs and assess correlation of MHSs with vertebral heart scores (VHSs). ANIMALS 120 clinically normal large-breed dogs (LBDs)
Ayman A, Mostafa, Clifford R, Berry
openaire   +2 more sources

Quasi-Experimental Study: Perceived Attitude Toward Dogs, Dog Breed/Size and Public Accommodation

, 2020
The purpose of this research was to determine if service dog breed, dog size, or a small business employee’s attitude toward dogs impacts their likelihood of public accommodation. Federal law prohibits businesses from denying service dogs access to their
Sloan, Kimberly K.
core  

Prion‐Like Protein LENG8‐Mediated Nucleation Drives Stress Granule Assembly

Advanced Science, EarlyView.
LENG8 is a newly identified stress granule (SG) nucleator required for SG assembly. Following stress, nuclear LENG8 granules disassemble, allowing LENG8 to translocate into the cytoplasm and form independent nucleation foci. These foci fuse with canonical early G3BP1/TIA1 seeds via LENG8‐TIA1 binding to drive SG maturation.
Mingxing Zhang, Xin Wang, Yilan Teng, Zhicheng Wu, Jing Fan, Hongwen Zhu, Peng Dai   +6 more
wiley   +1 more source

Age and sex predisposition to cranial cruciate ligament rupture in small breed dogs

RUDN Journal of Agronomy and Animal Industries
The rising prevalence of small and toy dog breeds in urban environments necessitates a deeper understanding of their breed-specific pathologies. Cranial cruciate ligament (CCL) rupture is a leading orthopedic cause of hindlimb lameness in dogs, yet ...
Kirill A. Kozlyakov, Sergey A. Yagnikov, Andrey D. Trukhachev, Lusine S. Barsegyan   +3 more
doaj   +1 more source

Supramolecular Zinc–Polyphenol Coordination Assemblies Mitigate Colonic Inflammation by Regulating Mucosal Barrier and Microbiome

Advanced Science, EarlyView.
A carrier‐free zinc‐coordinated polyphenol nanoplatform (ZnCA NPs) is designed as an “all‐in‐one” therapeutic strategy for intestinal inflammation. The ZnCA NPs exhibit enhanced colonic accumulation and broad‐spectrum reactive oxygen and nitrogen species scavenging.
Qiwen Xie, Mai Ye, Xuexia Liu, Jing Wang, Ying Chen, Lu Tan, Jinheng Fu, Xiaochang Huang   +7 more
wiley   +1 more source

Interleukin‐39 is a Prognostic Biomarker and Therapy Target for Sepsis

Advanced Science, EarlyView.
Sepsis triggers a significant increase in IL‐39 production, with circulating levels markedly elevated and positively correlated with disease severity and poor clinical prognosis in sepsis patients. Mechanistically, macrophage‐derived IL‐39 activates the GP130 signaling pathway via a ligand‐receptor interaction, thereby fueling the pro‐inflammatory ...
Feng‐zhi Zhang, Hai‐jun Liu, Yan Yue, Jun‐jie Gao, Jin Zhang, Wen‐wu Zhang, Yun‐long Zhang, Wei‐hua Lu, Sheng‐wei Jin, Pu‐hong Zhang   +9 more
wiley   +1 more source

TNAP and PHOSPHO1 Function Synergistically to Afford Critical Control Over the Mineralization of the Postnatal Murine Skeleton

Advanced Science, EarlyView.
Biomineralization underpins skeletal development, yet its molecular control remains incompletely understood. Using a novel murine knockout model, this study reveals the essential and complementary roles of PHOSPHO1 and TNAP in postnatal skeletal development.
Lucie E. Bourne, Aikta Sharma, Scott Dillon, Jacob Keen, Soher N. Jayash, Natalie Crump, Lucinda A.E. Evans, Maya Karmali, Worachet Promruk, Claire E. Clarkin, Sonoko Narisawa, Louise Stephen, Brian L. Foster, José Luis Millán, Colin Farquharson, Katherine A. Staines   +15 more
wiley   +1 more source

Clinical application of 3D printing technology to the surgical treatment of atlantoaxial subluxation in small breed dogs.

PLoS ONE, 2019
Atlantoaxial instability (AAI)/subluxation commonly occurs in small breed dogs. Ventral stabilization techniques using screws and/or pins and a plate or, more commonly, polymethylmethacrylate are considered to provide the most favorable outcome. However,
Hiroaki Kamishina, Taku Sugawara, Kohei Nakata, Hidetaka Nishida, Naoko Yada, Toru Fujioka, Yoshihiko Nagata, Akio Doi, Naoyuki Konno, Fujio Uchida, Sadatoshi Maeda   +10 more
doaj   +1 more source

Risk factors assessment and antimicrobial resistance of Salmonella isolates from apparently healthy and diarrheal dogs in Baghdad, Iraq [PDF]

Iraqi Journal of Veterinary Sciences
The dog was an essential source of Salmonella (S.) transmission. One hundred sixty-five rectal swabs were taken from apparently healthy dogs (90) and diarrheal dogs (75) in Baghdad province, Iraq. The Salmonella species was found using standard bacterial
Fadhaa H. Abdullah, Nagham M. Al-Gburi
doaj   +1 more source