Results 161 to 170 of about 19,700,178 (306)

Correction: Radioprotective effects of ultra-small citrate-stabilized cerium oxide nanoparticles <i>in vitro</i> and <i>in vivo</i>. [PDF]

RSC Adv
Popov AL, Zaichkina SI, Popova NR, Rozanova OM, Romanchenko SP, Ivanova OS, Smirnov AA, Mironova EV, Selezneva II, Ivanov VK.   +9 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

DTI-ALPS as a Biomarker of Small Vessel Disease Progression and Amyloid-β in Normal Aging: A 3-Year Longitudinal Study. [PDF]

Hum Brain Mapp
Azizi N, Borooghani H, Kiani I, Gharaylou Z, Seyedi D, Firouznia K, Kolahi S.   +6 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Host diversity and landscape structure drive genospecies-specific Lyme disease risk across Eurasia. [PDF]

One Health
Sun Y, Zhang Y, Wang J, Fang R, Guo Y, Li S.   +5 more
europepmc   +1 more source

Effects of small-scale turbulence on dinoflagellate ecophysiology

, 2011
Spanish projects: TURFI (REN2002-01591/MAR), TURDITOX (CTM2005-03547/MAR), TURECOTOX (CTM2006-13884-C02-00/MAR) VARITEC (CTM2004-04442-C02). G. Llaveria fue becaria FPU del MICINN (2004-2008)
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Thalassorama: Economic Viability of Small-scale Marine Capture Fisheries in the Bonny Area, Rivers State, Nigeria [PDF]

Small-scale, costs, earnings, returns, Environmental Economics and Policy, International Development, Production Economics, Public Economics, Q,
Abohweyere, P.O., Tanko, Alhaji, Jim-Saiki, L., Adeogun, O.A., Ogunbadejo, H.K.   +4 more
core  

Can big data answer the big questions about specific mental disorders? The example of obsessive-compulsive disorder. [PDF]

World Psychiatry
Simpson HB, Wall M.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source