Results 51 to 60 of about 12,713 (265)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

The role of certifications and eco-labels in fisheries: a systematic literature review of their benefits and challenges

Environmental Sciences Europe
Eco-labels are market tools that provide consumers with relevant information, enabling more informed and sustainable purchasing decisions. As fisheries operate on a high production scale, it is possible to dilute the costs of implementing and maintaining
Marília Tenório Gouveia de Melo, Jheyce Milena da Silva Barros, Ana Regina Bezerra Ribeiro, Telma Lucia de Andrade Lima, Marcos Felipe Falcão Sobral   +4 more
doaj   +1 more source

Exploring Policy of Small-Scale Coastal Fisheries in China: Evolution, Challenges and Prospects

Fishes
China plays a significant role in the global fishing industry. The small-scale fisheries (SSFs) operating along its coast have made noteworthy and invaluable contributions in the areas of poverty alleviation, protein provision, social equity, and overall
Minsi Xiong, Zuli Wu, Guangrui Qi, Keji Jiang, Na Zhao, Wei Jiang   +5 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Managing small-scale fisheries in Colombia

Maritime Studies, 2016
The small-scale fishermen of Colombia face a wide range of problems and conflicts. While many problems are shared among individuals from both the Atlantic and the Pacific coasts (bi-coastal), others are unique to a subset of the communities, only occur on one of the coasts (uni-coastal) or in an individual locality.
Saavedra-Díaz, Lina M., Pomeroy, Robert, Rosenberg, Andrew A.   +2 more
openaire   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Disentangling the complexity of tropical small-scale fisheries dynamics using supervised Self-Organizing Maps.

PLoS ONE, 2018
Tropical small-scale fisheries are typical for providing complex multivariate data, due to their diversity in fishing techniques and highly diverse species composition.
Manuel Mendoza-Carranza, Elisabet Ejarque, Leopold A J Nagelkerke   +2 more
doaj   +1 more source

Application of a multi-annual generalized depletion model to the assessment of a data-limited coastal fishery in the western Mediterranean

Scientia Marina, 2015
A multi-annual generalized depletion model was applied to a coastal fishery in Vilanova i la Geltrú (western Mediterranean) to assess the exploitation status of striped red mullet (Mullus surmuletus) and cuttlefish (Sepia officinalis), two of the main ...
Francesc Maynou
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source