Results 51 to 60 of about 9,653,323 (301)

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A data-limited approach to determine the status of the artisanal fishery of sea silverside in southern Chile

Marine and Fishery Sciences, 2022
Artisanal fisheries are essential, but for most the status of the stock supporting the fishing activity remains unknown due to lack of data and difficult access to sampling. For example, the artisanal fishery of sea silverside Odontesthes (Austromenidia)
Paulo Mora, Guillermo Figueroa-Muñoz, Luis Cubillos, Poliana Strange-Olate   +3 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Integrating Science-Based Co-management, Partnerships, Participatory Processes and Stewardship Incentives to Improve the Performance of Small-Scale Fisheries

Frontiers in Marine Science, 2017
Small scale fisheries are critically important for the provision of food security, livelihoods, and economic development for billions of people. Yet, most of these fisheries appear to not be achieving either fisheries or conservation goals, with respect ...
Kendra A. Karr, Rod Fujita, Ramon Carcamo, Lawrence Epstein, James R. Foley, José A. Fraire-Cervantes, Mauro Gongora, Ollin T. Gonzalez-Cuellar, Pablo Granados-Dieseldorff, Julius Guirjen, Amy H. Weaver, Héctor Licón-González, Emilie Litsinger, Julio Maaz, Roquelito Mancao, Valerie Miller, Rafael Ortiz-Rodriguez, Tomás Plomozo-Lugo, Laura F. Rodriguez-Harker, Salvador Rodríguez-Van Dyck, Aristóteles Stavrinaky, Cristina Villanueva-Aznar, Beverly Wade, Daniel Whittle, Jacob P. Kritzer   +24 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Cooperative Research to Evaluate an Incidental Catch Distribution Forecast

Frontiers in Marine Science, 2017
Concern over incidental catches in commercial fisheries has been increasing, and while simple mitigation strategies have been effective, few effective mitigation strategies have been established for more complex species interactions.
Sara M. Turner, Jonathan A. Hare, John P. Manderson, John J. Hoey, David E. Richardson, Christopher L. Sarro, Ryan Silva   +6 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Biological and fishery indicators for the small-scale marble crab fishery in Northern Patagonia: recommendations for improving a monitoring program and stock assessment of a data-limited fishery

Frontiers in Marine Science
Small-scale fisheries have been typically data-limited despite their economic importance for local communities. This is especially true in zones where fishing operations occur in remote areas under harsh weather conditions.
Madeleine Hamamé, Gustavo Aedo, Gustavo Aedo, Paula Ortiz, Andrés Olguín, Luis Miguel Pardo, Luis Miguel Pardo   +6 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source